Component

Trait anxiety

Independent cellular process record; interpretation is limited by each linked claim and its study context.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The Ghana trial found no significant lysine-placebo difference in trait-anxiety change or skin-conductance stress responses.

    L-Lysine → Trait anxiety source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Randomized placebo-controlled community trial using 1 g/day
    limitations
    Only a subset was at estimated dietary inadequacy risk; within-group improvement does not show treatment efficacy.
    organism
    Homo sapiens
    plain_language
    Questionnaire anxiety improved in both groups, without a lysine-specific difference.
    primary_references
    [ghosh2010] Effect of lysine supplementation on health and morbidity in subjects belonging to poor peri-urban households in Accra, Ghana (2010). https://www.sciencedirect.com/science/article/pii/S0002916523019640 DOI: 10.3945/ajcn.2009.28834
    tissue_or_cell_type
    Behavioral questionnaires and skin conductance

    L-Lysine: mechanism-first literature curation (2026-09-17) · lines 709–717

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo-controlled community trial using 1 g/day · source_derived_draft · unverified_draft

    ### ghana-anxiety-null The Ghana trial found no significant lysine-placebo difference in trait-anxiety change or skin-conductance stress responses. Plain language: Questionnaire anxiety improved in both groups, without a lysine-specific difference. Condition category: normal organism: Homo sapiens tissue_or_cell_type: Behavioral questionnaires and skin conductance experimental_model: Randomized placebo-controlled community trial using 1 g/day limitations: Only a subset was at estimated dietary inadequacy risk; within-group improvement does not show treatment efficacy. [ghosh2010] Effect of lysine supplementation on health and morbidity in subjects belonging to poor peri-urban households in Accra, Ghana (2010). https://www.sciencedirect.com/science/article/pii/S0002916523019640 DOI: 10.3945/ajcn.2009.28834
    Complete structured claim and evidence

  2. Syrian wheat fortification reduced trait-anxiety scores in men, with benefit concentrated in those with high baseline anxiety; women showed no trait-anxiety effect.

    L-Lysine → Trait anxiety source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    experimental_model
    Three-month randomized household trial
    limitations
    Dietary estimates, not individual biochemical diagnosis; one questionnaire; cannot establish treatment of anxiety disorders.
    organism
    Homo sapiens
    plain_language
    The anxiety result was subgroup-specific in a population with probable dietary inadequacy.
    primary_references
    [smriga2004] Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria (2004). https://pmc.ncbi.nlm.nih.gov/articles/PMC420386/ DOI: 10.1073/pnas.0402550101
    tissue_or_cell_type
    Behavioral questionnaire outcome
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    L-Lysine: mechanism-first literature curation (2026-09-17) · lines 689–697

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Three-month randomized household trial · source_derived_draft · unverified_draft

    ### syria-trait-anxiety Syrian wheat fortification reduced trait-anxiety scores in men, with benefit concentrated in those with high baseline anxiety; women showed no trait-anxiety effect. Plain language: The anxiety result was subgroup-specific in a population with probable dietary inadequacy. Condition category: nutrient_deficiency organism: Homo sapiens tissue_or_cell_type: Behavioral questionnaire outcome experimental_model: Three-month randomized household trial limitations: Dietary estimates, not individual biochemical diagnosis; one questionnaire; cannot establish treatment of anxiety disorders. [smriga2004] Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria (2004). https://pmc.ncbi.nlm.nih.gov/articles/PMC420386/ DOI: 10.1073/pnas.0402550101
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. One week of combined lysine and arginine reduced trait and stress-induced state anxiety in a randomized trial of 108 healthy Japanese adults.

    L-Lysine → Trait and stress-induced state anxiety source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Randomized double-blind placebo-controlled trial; 2.64 g/day of each amino acid
    limitations
    Short duration; no lysine-only arm; no established treatment effect for diagnosed anxiety disorders.
    organism
    Homo sapiens
    plain_language
    The tested mixture improved anxiety scores; the contribution of lysine alone is unknown.
    primary_references
    [smriga2007] Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans (2007). https://pubmed.ncbi.nlm.nih.gov/17510493/ DOI: 10.2220/biomedres.28.85
    tissue_or_cell_type
    Behavioral questionnaires

    L-Lysine: mechanism-first literature curation (2026-09-17) · lines 729–737

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial; 2.64 g/day of each amino acid · source_derived_draft · unverified_draft

    ### lysine-arginine-anxiety One week of combined lysine and arginine reduced trait and stress-induced state anxiety in a randomized trial of 108 healthy Japanese adults. Plain language: The tested mixture improved anxiety scores; the contribution of lysine alone is unknown. Condition category: normal organism: Homo sapiens tissue_or_cell_type: Behavioral questionnaires experimental_model: Randomized double-blind placebo-controlled trial; 2.64 g/day of each amino acid limitations: Short duration; no lysine-only arm; no established treatment effect for diagnosed anxiety disorders. [smriga2007] Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans (2007). https://pubmed.ncbi.nlm.nih.gov/17510493/ DOI: 10.2220/biomedres.28.85
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards