{"id":"9f21b3d8-f1b5-588b-9a38-46f11a8ba9cd","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:syria-trait-anxiety","predicate":"fortification_reduced_in_male_subgroup","statement":"Syrian wheat fortification reduced trait-anxiety scores in men, with benefit concentrated in those with high baseline anxiety; women showed no trait-anxiety effect.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b22a25e4-c82f-5833-8b5f-ffeed65a19b2","mechanism_event_label":"The anxiety result was subgroup-specific in a population with probable dietary inadequacy.","subject":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"object":{"id":"aa767f96-856c-55d1-89bc-587586ee0210","slug":"trait-anxiety","display_name":"Trait anxiety","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b22a25e4-c82f-5833-8b5f-ffeed65a19b2","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:syria-trait-anxiety-event","event_type":"observed_intervention","label":"The anxiety result was subgroup-specific in a population with probable dietary inadequacy.","description":"Syrian wheat fortification reduced trait-anxiety scores in men, with benefit concentrated in those with high baseline anxiety; women showed no trait-anxiety effect.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aa767f96-856c-55d1-89bc-587586ee0210","slug":"trait-anxiety","display_name":"Trait anxiety","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Three-month randomized household trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Dietary estimates, not individual biochemical diagnosis; one questionnaire; cannot establish treatment of anxiety disorders.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The anxiety result was subgroup-specific in a population with probable dietary inadequacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[smriga2004] Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria (2004). https://pmc.ncbi.nlm.nih.gov/articles/PMC420386/ DOI: 10.1073/pnas.0402550101","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Behavioral questionnaire outcome","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"697db2f9-ecca-5dd0-ae01-0770fd9a10b9","evidence_kind":"source_excerpt","locator":"Lines 689-697","start_line":689,"end_line":697,"excerpt":"### syria-trait-anxiety\nSyrian wheat fortification reduced trait-anxiety scores in men, with benefit concentrated in those with high baseline anxiety; women showed no trait-anxiety effect.\nPlain language: The anxiety result was subgroup-specific in a population with probable dietary inadequacy.\nCondition category: nutrient_deficiency\norganism: Homo sapiens\ntissue_or_cell_type: Behavioral questionnaire outcome\nexperimental_model: Three-month randomized household trial\nlimitations: Dietary estimates, not individual biochemical diagnosis; one questionnaire; cannot establish treatment of anxiety disorders.\n[smriga2004] Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria (2004). https://pmc.ncbi.nlm.nih.gov/articles/PMC420386/ DOI: 10.1073/pnas.0402550101","model_system":"Three-month randomized household trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [smriga2004] Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria (2004). https://pmc.ncbi.nlm.nih.gov/articles/PMC420386/ DOI: 10.1073/pnas.0402550101","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[{"id":"878b52bb-6044-5c84-a68a-897a968fe7cb","title":"Dietary fortification and a later community trial differ on anxiety","kind":"context_difference","status":"open","why":"Baseline diet, estimated inadequacy, initial anxiety, delivery, and setting differed. These are inconsistent effectiveness findings across contexts; differences are possible explanations, not demonstrated resolutions.","resolution":"Unresolved; needs review.","created_at":"2026-09-17 07:46:03","record_type":"conflict","display_label":"Recorded conflict","record_url":"/conflicts/878b52bb-6044-5c84-a68a-897a968fe7cb","sides":[{"conflict_id":"878b52bb-6044-5c84-a68a-897a968fe7cb","ordinal":0,"label":"Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","start_line":689,"end_line":697,"quote":"### syria-trait-anxiety\nSyrian wheat fortification reduced trait-anxiety scores in men, with benefit concentrated in those with high baseline anxiety; women showed no trait-anxiety effect.\nPlain language: The anxiety result was subgroup-specific in a population with probable dietary inadequacy.\nCondition category: nutrient_deficiency\norganism: Homo sapiens\ntissue_or_cell_type: Behavioral questionnaire outcome\nexperimental_model: Three-month randomized household trial\nlimitations: Dietary estimates, not individual biochemical diagnosis; one questionnaire; cannot establish treatment of anxiety disorders.\n[smriga2004] Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria (2004). https://pmc.ncbi.nlm.nih.gov/articles/PMC420386/ DOI: 10.1073/pnas.0402550101","source_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","source_title":"L-Lysine: mechanism-first literature curation (2026-09-17)","claim_ids":["9f21b3d8-f1b5-588b-9a38-46f11a8ba9cd"]},{"conflict_id":"878b52bb-6044-5c84-a68a-897a968fe7cb","ordinal":1,"label":"Effect of lysine supplementation on health and morbidity in subjects belonging to poor peri-urban households in Accra, Ghana","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","start_line":709,"end_line":717,"quote":"### ghana-anxiety-null\nThe Ghana trial found no significant lysine-placebo difference in trait-anxiety change or skin-conductance stress responses.\nPlain language: Questionnaire anxiety improved in both groups, without a lysine-specific difference.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Behavioral questionnaires and skin conductance\nexperimental_model: Randomized placebo-controlled community trial using 1 g/day\nlimitations: Only a subset was at estimated dietary inadequacy risk; within-group improvement does not show treatment efficacy.\n[ghosh2010] Effect of lysine supplementation on health and morbidity in subjects belonging to poor peri-urban households in Accra, Ghana (2010). https://www.sciencedirect.com/science/article/pii/S0002916523019640 DOI: 10.3945/ajcn.2009.28834","source_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","source_title":"L-Lysine: mechanism-first literature curation (2026-09-17)","claim_ids":["1c470d56-715e-5547-a157-70218b88a4c1"]}]}],"corrections":[],"research":null}