Component
Total cholesterol concentration
Total cholesterol concentration. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Oat beta-glucan in doses at or above 3 grams per day reduced low-density lipoprotein and total cholesterol relative to control by 0.25 mmol/L with 95% CI 0.20 to 0.30 and 0.30 mmol/L with 95% CI 0.24 to 0.35 respectively, there was no significant effect on high-density lipoprotein cholesterol or triglycerides and no evidence that dose across a range of 3.0 to 12.4 grams per day or duration of treatment from 2 to 12 weeks influenced the results, and LDL cholesterol lowering was significantly greater with higher baseline LDL cholesterol.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/glucan-research/25411276.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "33075c61a20f22975ba8719b6ef8834ce254f1d4e3ede6ca5d89cd4d81a82b28", "start_char": 0, "end_char": 2072, "text_sha256": "33075c61a20f22975ba8719b6ef8834ce254f1d4e3ede6ca5d89cd4d81a82b28"}
- experimental_model
- Random-effects meta-analysis and meta-regression of 28 randomised controlled trials at or above 3 grams per day
- exposure
- Oat beta-glucan at 3.0 to 12.4 grams per day against an appropriate control for 2 to 12 weeks
- limitations
- A meta-analysis with some indication of heterogeneity. The diabetes subgroup rests on few studies, and in-house study reports from a commercial source were among those searched.
- nutrient_topic
- Beta-glucan research collection; topical membership is not evidence of a direct clinical effect, and each preparation is recorded as its own entity with no family link joining any pair. · Beta-glucan
- organism
- Human
- plain_language
- Three grams a day takes about a quarter of a millimole off the harmful cholesterol and leaves the other lipids alone.
- primary_references
- [bg-p25411276] Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials. (2014). https://pubmed.ncbi.nlm.nih.gov/25411276/ DOI: 10.3945/ajcn.114.086108
- tissue_or_cell_type
- Serum lipids
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Random-effects meta-analysis and meta-regression of 28 randomised controlled trials at or above 3 grams per day · source_derived_draft · unverified_draft
### bg-oat-glucan-lowers-ldl Oat beta-glucan in doses at or above 3 grams per day reduced low-density lipoprotein and total cholesterol relative to control by 0.25 mmol/L with 95% CI 0.20 to 0.30 and 0.30 mmol/L with 95% CI 0.24 to 0.35 respectively, there was no significant effect on high-density lipoprotein cholesterol or triglycerides and no evidence that dose across a range of 3.0 to 12.4 grams per day or duration of treatment from 2 to 12 weeks influenced the results, and LDL cholesterol lowering was significantly greater with higher baseline LDL cholesterol. Condition category: normal nutrient_topic: Beta-glucan research collection; topical membership is not evidence of a direct clinical effect, and each preparation is recorded as its own entity with no family link joining any pair. plain_language: Three grams a day takes about a quarter of a millimole off the harmful cholesterol and leaves the other lipids alone. organism: Human tissue_or_cell_type: Serum lipids experimental_model: Random-effects meta-analysis and meta-regression of 28 randomised controlled trials at or above 3 grams per day limitations: A meta-analysis with some indication of heterogeneity. The diabetes subgroup rests on few studies, and in-house study reports from a commercial source were among those searched. exposure: Oat beta-glucan at 3.0 to 12.4 grams per day against an appropriate control for 2 to 12 weeks evidence_span: {"source_cache": "artifacts/glucan-research/25411276.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "33075c61a20f22975ba8719b6ef8834ce254f1d4e3ede6ca5d89cd4d81a82b28", "start_char": 0, "end_char": 2072, "text_sha256": "33075c61a20f22975ba8719b6ef8834ce254f1d4e3ede6ca5d89cd4d81a82b28"} [bg-p25411276] Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials. (2014). https://pubmed.ncbi.nlm.nih.gov/25411276/ DOI: 10.3945/ajcn.114.086108
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.