Component
TMEM189
Enzyme that forms the vinyl ether bond of plasmenylethanolamine downstream of plasmanyl-PE synthesis.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
TMEM189/PEDS1 introduces the vinyl ether double bond that converts plasmanyl-PE to plasmenyl-PE.
Experimental context and source evidence
- cell_type
- HAP1 cells and tissues
- experimental_model
- Knockout and rescue
- limitations
- TMEM189 is not a selenoprotein; reaction is downstream of SELENOI.
- organism
- human and mouse
Selenium: literature corrections and mechanism additions · lines 750–760
Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually · supports · Knockout and rescue · secondary_verified · secondary_verified
## tmem189-forms-plasmenyl-pe A separate enzyme completes the characteristic plasmalogen bond. TMEM189/PEDS1 introduces the vinyl ether double bond that converts plasmanyl-PE to plasmenyl-PE. Organism: human and mouse Cell type: HAP1 cells and tissues Experimental model: Knockout and rescue Limitations: TMEM189 is not a selenoprotein; reaction is downstream of SELENOI. Primary reference: [The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens](https://pubmed.ncbi.nlm.nih.gov/32209662/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.