Component
Tibial volumetric bone mineral density
Study-defined Tibial volumetric bone mineral density. Read each linked record for species, exposure and endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Tibial BMD differences versus 400 IU/day were−1.8 mgHA/cm³ with 4000 IU (95% CI−3.7 to 0.1; not significant) and−4.1 mgHA/cm³ with 10000 IU (CI−6.0 to−2.2).
Experimental context and source evidence
- cross_nutrient
- true
- experimental_model
- 311 healthy adults 55–70 randomized to daily 400, 4000, 10000 IU D3 for 3 years; 287 completed
- exposure
- D3 400, 4000 or 10000 IU/day for 3 years; calcium added for dietary intake<1200 mg/day.
- limitations
- Adults without osteoporosis, baseline 25(OH)D30–125 nmol/L; surrogate outcomes, not a deficiency-repletion trial or fracture endpoint.
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens
- plain_language
- The tibial result depended on dose; the lower comparison included no difference.
- primary_references
- [burt2019] Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31454046/ DOI: 10.1001/jama.2019.11889
- tissue_or_cell_type
- Tibia
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1613–1624
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 311 healthy adults 55–70 randomized to daily 400, 4000, 10000 IU D3 for 3 years; 287 completed · source_derived_draft · unverified_draft
### vd-burt-tibia Tibial BMD differences versus 400 IU/day were−1.8 mgHA/cm³ with 4000 IU (95% CI−3.7 to 0.1; not significant) and−4.1 mgHA/cm³ with 10000 IU (CI−6.0 to−2.2). Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The tibial result depended on dose; the lower comparison included no difference. organism: Homo sapiens tissue_or_cell_type: Tibia experimental_model: 311 healthy adults 55–70 randomized to daily 400, 4000, 10000 IU D3 for 3 years; 287 completed limitations: Adults without osteoporosis, baseline 25(OH)D30–125 nmol/L; surrogate outcomes, not a deficiency-repletion trial or fracture endpoint. exposure: D3 400, 4000 or 10000 IU/day for 3 years; calcium added for dietary intake<1200 mg/day. cross_nutrient: true [burt2019] Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31454046/ DOI: 10.1001/jama.2019.11889
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.