{"id":"d8ad0ee4-9c7b-5761-9f21-fc5ea1000168","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-burt-tibia","predicate":"has-dose-dependent-density-difference","statement":"Tibial BMD differences versus 400 IU/day were−1.8 mgHA/cm³ with 4000 IU (95% CI−3.7 to 0.1; not significant) and−4.1 mgHA/cm³ with 10000 IU (CI−6.0 to−2.2).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7d230754-dcaa-5358-bb2f-2250c611f6cc","mechanism_event_label":"The tibial result depended on dose; the lower comparison included no difference.","subject":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"object":{"id":"16443b96-04ec-5153-aa73-f61339a066e3","slug":"tibial-volumetric-bone-mineral-density","display_name":"Tibial volumetric bone mineral density","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7d230754-dcaa-5358-bb2f-2250c611f6cc","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-burt-tibia-event","event_type":"observed_intervention","label":"The tibial result depended on dose; the lower comparison included no difference.","description":"Tibial BMD differences versus 400 IU/day were−1.8 mgHA/cm³ with 4000 IU (95% CI−3.7 to 0.1; not significant) and−4.1 mgHA/cm³ with 10000 IU (CI−6.0 to−2.2).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"conditional-cointervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"16443b96-04ec-5153-aa73-f61339a066e3","slug":"tibial-volumetric-bone-mineral-density","display_name":"Tibial volumetric bone mineral density","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"311 healthy adults 55–70 randomized to daily 400, 4000, 10000 IU D3 for 3 years; 287 completed","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"D3 400, 4000 or 10000 IU/day for 3 years; calcium added for dietary intake<1200 mg/day.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Adults without osteoporosis, baseline 25(OH)D30–125 nmol/L; surrogate outcomes, not a deficiency-repletion trial or fracture endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The tibial result depended on dose; the lower comparison included no difference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[burt2019] Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31454046/ DOI: 10.1001/jama.2019.11889","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Tibia","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"585347fa-09ef-52f1-86a6-f4cac3891ccc","evidence_kind":"source_excerpt","locator":"Lines 1613-1624","start_line":1613,"end_line":1624,"excerpt":"### vd-burt-tibia\nTibial BMD differences versus 400 IU/day were−1.8 mgHA/cm³ with 4000 IU (95% CI−3.7 to 0.1; not significant) and−4.1 mgHA/cm³ with 10000 IU (CI−6.0 to−2.2).\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The tibial result depended on dose; the lower comparison included no difference.\norganism: Homo sapiens\ntissue_or_cell_type: Tibia\nexperimental_model: 311 healthy adults 55–70 randomized to daily 400, 4000, 10000 IU D3 for 3 years; 287 completed\nlimitations: Adults without osteoporosis, baseline 25(OH)D30–125 nmol/L; surrogate outcomes, not a deficiency-repletion trial or fracture endpoint.\nexposure: D3 400, 4000 or 10000 IU/day for 3 years; calcium added for dietary intake<1200 mg/day.\ncross_nutrient: true\n[burt2019] Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31454046/ DOI: 10.1001/jama.2019.11889","model_system":"311 healthy adults 55–70 randomized to daily 400, 4000, 10000 IU D3 for 3 years; 287 completed","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [burt2019] Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31454046/ DOI: 10.1001/jama.2019.11889","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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