Component
Thyroid peroxidase activity
Thyroid peroxidase activity. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Iron-deficiency anemia independently reduced thyroid peroxidase activity after accounting for food restriction in the rat experiment.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/iron-research/12097675.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "26b7a5ddb0985abdb2325c7ecd505c46f02604bd4d35f68ed0c9ad67113a148e", "start_char": 0, "end_char": 1527, "text_sha256": "26b7a5ddb0985abdb2325c7ecd505c46f02604bd4d35f68ed0c9ad67113a148e"}
- experimental_model
- Controlled iron-deficient diets with pair-fed controls
- exposure
- Four weeks of graded iron restriction; separate food-restriction controls
- limitations
- Food restriction also reduced TPO; the iron effect was separately estimated. No human serum threshold or automatic iodine-treatment failure rule.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- 84 male weanling rats
- plain_language
- Iodine supply is only part of thyroid-hormone synthesis; its working enzyme also depends on iron-containing heme.
- primary_references
- [iron-p12097675] Iron deficiency anemia reduces thyroid peroxidase activity in rats. (2002). https://pubmed.ncbi.nlm.nih.gov/12097675/ DOI: 10.1093/jn/132.7.1951
- tissue_or_cell_type
- Thyroid and blood
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 901–912
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled iron-deficient diets with pair-fed controls · source_derived_draft · unverified_draft
### iron-iron-tpo-deficiency Iron-deficiency anemia independently reduced thyroid peroxidase activity after accounting for food restriction in the rat experiment. Condition category: nutrient_deficiency nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Iodine supply is only part of thyroid-hormone synthesis; its working enzyme also depends on iron-containing heme. organism: 84 male weanling rats tissue_or_cell_type: Thyroid and blood experimental_model: Controlled iron-deficient diets with pair-fed controls limitations: Food restriction also reduced TPO; the iron effect was separately estimated. No human serum threshold or automatic iodine-treatment failure rule. exposure: Four weeks of graded iron restriction; separate food-restriction controls evidence_span: {"source_cache": "artifacts/iron-research/12097675.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "26b7a5ddb0985abdb2325c7ecd505c46f02604bd4d35f68ed0c9ad67113a148e", "start_char": 0, "end_char": 1527, "text_sha256": "26b7a5ddb0985abdb2325c7ecd505c46f02604bd4d35f68ed0c9ad67113a148e"} [iron-p12097675] Iron deficiency anemia reduces thyroid peroxidase activity in rats. (2002). https://pubmed.ncbi.nlm.nih.gov/12097675/ DOI: 10.1093/jn/132.7.1951
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.