Component
Thyrocyte apical membrane
Follicular-cell membrane facing thyroid follicular lumen.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Ishii et al. detected human thyroid SLC26A7 staining predominantly on the apical side facing the follicular lumen.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Human thyroid tissue; recombinant human SLC26A7 in Nthy, MDCK, COS-7 and HEK293T cells; two affected siblings
- exposure
- SLC26A7 immunofluorescence with NIS/pendrin localization comparisons; Fig. 1.
- limitations
- Other studies report basolateral localization; antibody, tissue and experimental context remain relevant.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Homo sapiens
- plain_language
- One human thyroid study placed SLC26A7 mainly toward the follicular space.
- primary_references
- [iodine-trans-slc26a7-2019] Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A7. (2019). https://pubmed.ncbi.nlm.nih.gov/31372509/ DOI: 10.1038/s42003-019-0503-6
- tissue_or_cell_type
- Thyroid follicular tissue
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 323–334
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human thyroid tissue; recombinant human SLC26A7 in Nthy, MDCK, COS-7 and HEK293T cells; two affected siblings · source_derived_draft · unverified_draft
### iodine-trans-a7-apical2019 Ishii et al. detected human thyroid SLC26A7 staining predominantly on the apical side facing the follicular lumen. Condition category: normal nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: One human thyroid study placed SLC26A7 mainly toward the follicular space. organism: Homo sapiens tissue_or_cell_type: Thyroid follicular tissue experimental_model: Human thyroid tissue; recombinant human SLC26A7 in Nthy, MDCK, COS-7 and HEK293T cells; two affected siblings limitations: Other studies report basolateral localization; antibody, tissue and experimental context remain relevant. exposure: SLC26A7 immunofluorescence with NIS/pendrin localization comparisons; Fig. 1. cross_nutrient: false [iodine-trans-slc26a7-2019] Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A7. (2019). https://pubmed.ncbi.nlm.nih.gov/31372509/ DOI: 10.1038/s42003-019-0503-6
Complete structured claim and evidenceHuman thyroid immunolocalization detected pendrin at the apical membrane in a subset of follicular epithelial cells.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Human thyroid immunolocalization; separate rat FRTL-5 regulatory experiments
- exposure
- Peptide-specific antibody immunolocalization; thyroid specimens included Graves disease tissue.
- limitations
- Cell subset and tissue context matter; this does not establish pendrin as the only iodide exit route.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Homo sapiens
- plain_language
- Pendrin can face the thyroid’s hormone-making follicular space.
- primary_references
- [iodine-trans-pendrin-location2000] Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells. (2000). https://pubmed.ncbi.nlm.nih.gov/10650967/ DOI: 10.1210/endo.141.2.7303
- tissue_or_cell_type
- Thyroid follicular epithelium
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 284–295
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human thyroid immunolocalization; separate rat FRTL-5 regulatory experiments · source_derived_draft · unverified_draft
### iodine-trans-pendrin-apical Human thyroid immunolocalization detected pendrin at the apical membrane in a subset of follicular epithelial cells. Condition category: normal nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Pendrin can face the thyroid’s hormone-making follicular space. organism: Homo sapiens tissue_or_cell_type: Thyroid follicular epithelium experimental_model: Human thyroid immunolocalization; separate rat FRTL-5 regulatory experiments limitations: Cell subset and tissue context matter; this does not establish pendrin as the only iodide exit route. exposure: Peptide-specific antibody immunolocalization; thyroid specimens included Graves disease tissue. cross_nutrient: false [iodine-trans-pendrin-location2000] Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells. (2000). https://pubmed.ncbi.nlm.nih.gov/10650967/ DOI: 10.1210/endo.141.2.7303
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.