{"id":"e40d1e62-05e9-5b6e-b6f2-0eb189c31f17","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-trans-pendrin-apical","predicate":"localizes_to","statement":"Human thyroid immunolocalization detected pendrin at the apical membrane in a subset of follicular epithelial cells.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"15bf0c16-befb-55bf-8cb3-30f26190eac6","mechanism_event_label":"Pendrin can face the thyroid’s hormone-making follicular space.","subject":{"id":"57fef31d-e7e6-5b6f-aee1-77fb94592ce7","slug":"slc26a4","display_name":"Human pendrin / SLC26A4","entity_type_key":"protein"},"object":{"id":"f9698339-d5b7-509d-91c9-b22a39836df2","slug":"thyrocyte-apical-membrane","display_name":"Thyrocyte apical membrane","entity_type_key":"organelle"},"evidence_count":1,"mechanism_event":{"id":"15bf0c16-befb-55bf-8cb3-30f26190eac6","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-trans-pendrin-apical-event","event_type":"observed_intervention","label":"Pendrin can face the thyroid’s hormone-making follicular space.","description":"Human thyroid immunolocalization detected pendrin at the apical membrane in a subset of follicular epithelial cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"transported_substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"57fef31d-e7e6-5b6f-aee1-77fb94592ce7","slug":"slc26a4","display_name":"Human pendrin / SLC26A4","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f9698339-d5b7-509d-91c9-b22a39836df2","slug":"thyrocyte-apical-membrane","display_name":"Thyrocyte apical membrane","entity_type_key":"organelle"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human thyroid immunolocalization; separate rat FRTL-5 regulatory experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Peptide-specific antibody immunolocalization; thyroid specimens included Graves disease tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell subset and tissue context matter; this does not establish pendrin as the only iodide exit route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Pendrin can face the thyroid’s hormone-making follicular space.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iodine-trans-pendrin-location2000] Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells. (2000). https://pubmed.ncbi.nlm.nih.gov/10650967/ DOI: 10.1210/endo.141.2.7303","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Thyroid follicular epithelium","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"47d3a0c7-221c-55dd-a0dd-a9f184fc68bc","evidence_kind":"source_excerpt","locator":"Lines 284-295","start_line":284,"end_line":295,"excerpt":"### iodine-trans-pendrin-apical\nHuman thyroid immunolocalization detected pendrin at the apical membrane in a subset of follicular epithelial cells.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Pendrin can face the thyroid’s hormone-making follicular space.\norganism: Homo sapiens\ntissue_or_cell_type: Thyroid follicular epithelium\nexperimental_model: Human thyroid immunolocalization; separate rat FRTL-5 regulatory experiments\nlimitations: Cell subset and tissue context matter; this does not establish pendrin as the only iodide exit route.\nexposure: Peptide-specific antibody immunolocalization; thyroid specimens included Graves disease tissue.\ncross_nutrient: false\n[iodine-trans-pendrin-location2000] Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells. (2000). https://pubmed.ncbi.nlm.nih.gov/10650967/ DOI: 10.1210/endo.141.2.7303","model_system":"Human thyroid immunolocalization; separate rat FRTL-5 regulatory experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iodine-trans-pendrin-location2000] Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells. (2000). https://pubmed.ncbi.nlm.nih.gov/10650967/ DOI: 10.1210/endo.141.2.7303","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a4885eb6f58bad4a4514c958b63834619e57b10aa7f694aa97d0f65c7d36548f","revision_id":"ea8001a1-b576-5eda-a193-883c7ad59b73","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}