Component
Metabolic clearance rate of triiodothyronine
Metabolic clearance rate of triiodothyronine. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Repeated cold air exposure increased the oral metabolic clearance rate of T3 by 5.4 l/day/m2 and the disposal rate by 10.2 nmol/day/m2, and these increases were not dependent on thyrotropin or thyroxine, since they were unchanged in men given replacement T3 whose TSH and T4 fell by about half.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/cold-research/1636702.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4e0d8127d3ebb682588afd84b635d2607dce9ebec4e7573d25e7baae58fc9301", "start_char": 0, "end_char": 1183, "text_sha256": "4e0d8127d3ebb682588afd84b635d2607dce9ebec4e7573d25e7baae58fc9301"}
- experimental_model
- Sixteen men given oral T3 before, during and after 80 cold air exposures, with and without T3 replacement
- exposure
- Eighty exposures to 4 degrees C air, ten per week
- limitations
- Cold air rather than water immersion, recorded because it isolates the thyroid hormone kinetics. The pharmacological oral T3 dose is not physiological.
- nutrient_topic
- Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
- organism
- Human
- plain_language
- Cold makes the body consume active thyroid hormone faster, independently of the usual feedback loop.
- primary_references
- [cold-p1636702] Multiple cold air exposures change oral triiodothyronine kinetics in normal men. (1992). https://pubmed.ncbi.nlm.nih.gov/1636702/ DOI: 10.1152/ajpendo.1992.263.1.e85
- tissue_or_cell_type
- Whole body thyroid hormone kinetics
Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 676–687
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Sixteen men given oral T3 before, during and after 80 cold air exposures, with and without T3 replacement · source_derived_draft · unverified_draft
### cold-cold-t3-clearance Repeated cold air exposure increased the oral metabolic clearance rate of T3 by 5.4 l/day/m2 and the disposal rate by 10.2 nmol/day/m2, and these increases were not dependent on thyrotropin or thyroxine, since they were unchanged in men given replacement T3 whose TSH and T4 fell by about half. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Cold makes the body consume active thyroid hormone faster, independently of the usual feedback loop. organism: Human tissue_or_cell_type: Whole body thyroid hormone kinetics experimental_model: Sixteen men given oral T3 before, during and after 80 cold air exposures, with and without T3 replacement limitations: Cold air rather than water immersion, recorded because it isolates the thyroid hormone kinetics. The pharmacological oral T3 dose is not physiological. exposure: Eighty exposures to 4 degrees C air, ten per week evidence_span: {"source_cache": "artifacts/cold-research/1636702.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4e0d8127d3ebb682588afd84b635d2607dce9ebec4e7573d25e7baae58fc9301", "start_char": 0, "end_char": 1183, "text_sha256": "4e0d8127d3ebb682588afd84b635d2607dce9ebec4e7573d25e7baae58fc9301"} [cold-p1636702] Multiple cold air exposures change oral triiodothyronine kinetics in normal men. (1992). https://pubmed.ncbi.nlm.nih.gov/1636702/ DOI: 10.1152/ajpendo.1992.263.1.e85
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.