{"id":"672abc05-cbf6-5d03-bef2-98b0f71d2510","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-cold-t3-clearance","predicate":"is_cleared_faster_during","statement":"Repeated cold air exposure increased the oral metabolic clearance rate of T3 by 5.4 l/day/m2 and the disposal rate by 10.2 nmol/day/m2, and these increases were not dependent on thyrotropin or thyroxine, since they were unchanged in men given replacement T3 whose TSH and T4 fell by about half.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"1b048433-1ae0-5bb5-bdc1-98aa0a108ae6","mechanism_event_label":"Cold makes the body consume active thyroid hormone faster, independently of the usual feedback loop.","subject":{"id":"559f37d2-ee0a-589b-8689-fa80ca9ae653","slug":"triiodothyronine","display_name":"T3","entity_type_key":"small_molecule"},"object":{"id":"8183f9d9-2be1-54a9-b02c-5f250b08a403","slug":"t3-metabolic-clearance","display_name":"Metabolic clearance rate of triiodothyronine","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1b048433-1ae0-5bb5-bdc1-98aa0a108ae6","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-cold-t3-clearance-event","event_type":"observed_intervention","label":"Cold makes the body consume active thyroid hormone faster, independently of the usual feedback loop.","description":"Repeated cold air exposure increased the oral metabolic clearance rate of T3 by 5.4 l/day/m2 and the disposal rate by 10.2 nmol/day/m2, and these increases were not dependent on thyrotropin or thyroxine, since they were unchanged in men given replacement T3 whose TSH and T4 fell by about half.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e9e2013-a051-5aa2-87cc-a2660ee6afe0","slug":"thyrotropin","display_name":"Thyrotropin / TSH","entity_type_key":"protein"},"role":"independent_signal","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f2b25f38-ec94-57d0-a46d-dd0fee45f01e","slug":"thyroxine","display_name":"T4","entity_type_key":"small_molecule"},"role":"independent_precursor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5a017cd9-d916-5bc4-8606-e67fb4d14645","slug":"t3-disposal-rate","display_name":"Disposal rate of triiodothyronine","entity_type_key":"cellular_process"},"role":"co_measured","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"upstream_nutrient","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"559f37d2-ee0a-589b-8689-fa80ca9ae653","slug":"triiodothyronine","display_name":"T3","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"8183f9d9-2be1-54a9-b02c-5f250b08a403","slug":"t3-metabolic-clearance","display_name":"Metabolic clearance rate of triiodothyronine","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/cold-research/1636702.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4e0d8127d3ebb682588afd84b635d2607dce9ebec4e7573d25e7baae58fc9301\", \"start_char\": 0, \"end_char\": 1183, \"text_sha256\": \"4e0d8127d3ebb682588afd84b635d2607dce9ebec4e7573d25e7baae58fc9301\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sixteen men given oral T3 before, during and after 80 cold air exposures, with and without T3 replacement","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Eighty exposures to 4 degrees C air, ten per week","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cold air rather than water immersion, recorded because it isolates the thyroid hormone kinetics. The pharmacological oral T3 dose is not physiological.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Cold makes the body consume active thyroid hormone faster, independently of the usual feedback loop.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p1636702] Multiple cold air exposures change oral triiodothyronine kinetics in normal men. (1992). https://pubmed.ncbi.nlm.nih.gov/1636702/ DOI: 10.1152/ajpendo.1992.263.1.e85","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole body thyroid hormone kinetics","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2219811c-1665-5b1f-acaa-e4a1d11bb3e6","evidence_kind":"source_excerpt","locator":"Lines 676-687","start_line":676,"end_line":687,"excerpt":"### cold-cold-t3-clearance\nRepeated cold air exposure increased the oral metabolic clearance rate of T3 by 5.4 l/day/m2 and the disposal rate by 10.2 nmol/day/m2, and these increases were not dependent on thyrotropin or thyroxine, since they were unchanged in men given replacement T3 whose TSH and T4 fell by about half.\nCondition category: normal\nnutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: Cold makes the body consume active thyroid hormone faster, independently of the usual feedback loop.\norganism: Human\ntissue_or_cell_type: Whole body thyroid hormone kinetics\nexperimental_model: Sixteen men given oral T3 before, during and after 80 cold air exposures, with and without T3 replacement\nlimitations: Cold air rather than water immersion, recorded because it isolates the thyroid hormone kinetics. The pharmacological oral T3 dose is not physiological.\nexposure: Eighty exposures to 4 degrees C air, ten per week\nevidence_span: {\"source_cache\": \"artifacts/cold-research/1636702.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4e0d8127d3ebb682588afd84b635d2607dce9ebec4e7573d25e7baae58fc9301\", \"start_char\": 0, \"end_char\": 1183, \"text_sha256\": \"4e0d8127d3ebb682588afd84b635d2607dce9ebec4e7573d25e7baae58fc9301\"}\n[cold-p1636702] Multiple cold air exposures change oral triiodothyronine kinetics in normal men. (1992). https://pubmed.ncbi.nlm.nih.gov/1636702/ DOI: 10.1152/ajpendo.1992.263.1.e85","model_system":"Sixteen men given oral T3 before, during and after 80 cold air exposures, with and without T3 replacement","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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