Component
T-cell cytoplasmic calcium signal
T-cell cytoplasmic calcium signal; model and exposure are recorded in linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Higher extracellular zinc sustained the cytoplasmic calcium signal after T-cell activation; initial calcium rises were similar, then the signals diverged.
Experimental context and source evidence
- cross_nutrient
- calcium ion (signaling_ion); Human zinc transporter ZIP6 / SLC39A6 (upstream_transporter)
- evidence_span
- {"source_cache": "artifacts/zinc-signaling-sources/21422171.txt", "locator": "Results: zinc availability and TCR signaling; Figure 4e calcium time course", "file_sha256": "4d36b4fdeeff83b602b0532796814981ee45409241fe40fcd8f7bc1da8beff19"}
- experimental_model
- Primary human T-cell receptor signaling study
- exposure
- Receptor activation, extracellular zinc availability and ZIP6 suppression comparisons.
- limitations
- Culture zinc availability and local signals cannot be mapped directly to oral doses or plasma thresholds. Calcium fluorescence tracks the signal rather than proving one specific calcium channel mechanism.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Homo sapiens
- plain_language
- Zinc availability affected how long the calcium signal lasted.
- primary_references
- [zn-sig-21422171] Regulation of T cell receptor signaling by activation-induced zinc influx. (2011). https://pubmed.ncbi.nlm.nih.gov/21422171/ DOI: 10.1084/jem.20100031
- tissue_or_cell_type
- CD4 T cells at the receptor-contact region
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 1055–1067
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Primary human T-cell receptor signaling study · source_derived_draft · unverified_draft
### zn-sig-zinc-calcium-signal Higher extracellular zinc sustained the cytoplasmic calcium signal after T-cell activation; initial calcium rises were similar, then the signals diverged. Condition category: normal nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: Zinc availability affected how long the calcium signal lasted. organism: Homo sapiens tissue_or_cell_type: CD4 T cells at the receptor-contact region experimental_model: Primary human T-cell receptor signaling study limitations: Culture zinc availability and local signals cannot be mapped directly to oral doses or plasma thresholds. Calcium fluorescence tracks the signal rather than proving one specific calcium channel mechanism. exposure: Receptor activation, extracellular zinc availability and ZIP6 suppression comparisons. cross_nutrient: calcium ion (signaling_ion); Human zinc transporter ZIP6 / SLC39A6 (upstream_transporter) evidence_span: {"source_cache": "artifacts/zinc-signaling-sources/21422171.txt", "locator": "Results: zinc availability and TCR signaling; Figure 4e calcium time course", "file_sha256": "4d36b4fdeeff83b602b0532796814981ee45409241fe40fcd8f7bc1da8beff19"} [zn-sig-21422171] Regulation of T cell receptor signaling by activation-induced zinc influx. (2011). https://pubmed.ncbi.nlm.nih.gov/21422171/ DOI: 10.1084/jem.20100031
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.