Component

Human sulfotransferase 1A3 / SULT1A3

Human sulfotransferase 1A3 / SULT1A3. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Human SULT1A3 also catalyzed curcumin sulfation.

    Human sulfotransferase 1A3 / SULT1A3 → Curcumin sulfate source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/11815407.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "028fbc6d7e7e728f7e52970df07c8e9b04053abe4799669798d593369d2c23b8", "start_char": 0, "end_char": 2113, "text_sha256": "028fbc6d7e7e728f7e52970df07c8e9b04053abe4799669798d593369d2c23b8"}
    experimental_model
    Human and rat tissue fractions and enzyme assays
    exposure
    Curcumin incubated with tissue fractions or purified sulfotransferases
    limitations
    Ex-vivo metabolism does not measure whole-person bioavailability. Isoforms are specified only where experimentally identified.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Human assays below; rat experiments not merged
    plain_language
    A second sulfotransferase can process the same compound.
    primary_references
    [curcumin-p11815407] Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. (2002). https://pubmed.ncbi.nlm.nih.gov/11815407/
    tissue_or_cell_type
    Intestinal and hepatic microsomes and cytosol

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 125–136

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human and rat tissue fractions and enzyme assays · source_derived_draft · unverified_draft

    ### curcumin-sult1a3 Human SULT1A3 also catalyzed curcumin sulfation. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A second sulfotransferase can process the same compound. organism: Human assays below; rat experiments not merged tissue_or_cell_type: Intestinal and hepatic microsomes and cytosol experimental_model: Human and rat tissue fractions and enzyme assays limitations: Ex-vivo metabolism does not measure whole-person bioavailability. Isoforms are specified only where experimentally identified. exposure: Curcumin incubated with tissue fractions or purified sulfotransferases evidence_span: {"source_cache": "artifacts/curcumin-research/11815407.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "028fbc6d7e7e728f7e52970df07c8e9b04053abe4799669798d593369d2c23b8", "start_char": 0, "end_char": 2113, "text_sha256": "028fbc6d7e7e728f7e52970df07c8e9b04053abe4799669798d593369d2c23b8"} [curcumin-p11815407] Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. (2002). https://pubmed.ncbi.nlm.nih.gov/11815407/
    Complete structured claim and evidence

  2. The same study assigned intestinal EGCG sulfation to SULT1A3.

    Human sulfotransferase 1A3 / SULT1A3 → Epigallocatechin-3-gallate (EGCG) source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Human liver/intestinal cytosol, enzyme assignment and a human ingestion pharmacokinetic study.
    limitations
    Formation rate and metabolite exposure do not prove identical biological effects of free and conjugated EGCG.
    nutrient_topic
    EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
    plain_language
    A different enzyme contributed in the intestinal preparation.
    primary_references
    4″-Sulfation Is the Major Metabolic Pathway of Epigallocatechin-3-gallate in Humans: Characterization of Metabolites, Enzymatic Analysis, and Pharmacokinetic Profiling. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35786898/ · DOI 10.1021/acs.jafc.2c02150

    EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 284–290

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human liver/intestinal cytosol, enzyme assignment and a human ingestion pharmacokinetic study. · source_derived_draft · unverified_draft

    ## egcg-sult1a3 A different enzyme contributed in the intestinal preparation. The same study assigned intestinal EGCG sulfation to SULT1A3. Model: Human liver/intestinal cytosol, enzyme assignment and a human ingestion pharmacokinetic study. Limitations: Formation rate and metabolite exposure do not prove identical biological effects of free and conjugated EGCG. Evidence access: primary abstract. 4″-Sulfation Is the Major Metabolic Pathway of Epigallocatechin-3-gallate in Humans: Characterization of Metabolites, Enzymatic Analysis, and Pharmacokinetic Profiling. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35786898/ · DOI 10.1021/acs.jafc.2c02150
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards