{"id":"f2973af7-7216-5dab-b73a-05e93bdf885e","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-sult1a3","predicate":"sulfates","statement":"The same study assigned intestinal EGCG sulfation to SULT1A3.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b179307f-5729-5e37-a735-0c5fd9b55954","mechanism_event_label":"A different enzyme contributed in the intestinal preparation.","subject":{"id":"3aa06e5b-44c9-5ebb-8b61-0a06f5e808a1","slug":"sult1a3","display_name":"Human sulfotransferase 1A3 / SULT1A3","entity_type_key":"protein"},"object":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"b179307f-5729-5e37-a735-0c5fd9b55954","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-sult1a3-event","event_type":"observed_relationship","label":"A different enzyme contributed in the intestinal preparation.","description":"The same study assigned intestinal EGCG sulfation to SULT1A3.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3aa06e5b-44c9-5ebb-8b61-0a06f5e808a1","slug":"sult1a3","display_name":"Human sulfotransferase 1A3 / SULT1A3","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0d47b6ae-dd61-5f07-918d-689e33248822","slug":"egcg-4-double-prime-sulfate","display_name":"EGCG-4″-sulfate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Human liver/intestinal cytosol, enzyme assignment and a human ingestion pharmacokinetic study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Formation rate and metabolite exposure do not prove identical biological effects of free and conjugated EGCG.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A different enzyme contributed in the intestinal preparation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"4″-Sulfation Is the Major Metabolic Pathway of Epigallocatechin-3-gallate in Humans: Characterization of Metabolites, Enzymatic Analysis, and Pharmacokinetic Profiling. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35786898/ · DOI 10.1021/acs.jafc.2c02150","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"eaa3be56-6062-555b-a3dc-6b4a2a0fae99","evidence_kind":"source_excerpt","locator":"Lines 284-290","start_line":284,"end_line":290,"excerpt":"## egcg-sult1a3\nA different enzyme contributed in the intestinal preparation.\nThe same study assigned intestinal EGCG sulfation to SULT1A3.\nModel: Human liver/intestinal cytosol, enzyme assignment and a human ingestion pharmacokinetic study.\nLimitations: Formation rate and metabolite exposure do not prove identical biological effects of free and conjugated EGCG.\nEvidence access: primary abstract.\n4″-Sulfation Is the Major Metabolic Pathway of Epigallocatechin-3-gallate in Humans: Characterization of Metabolites, Enzymatic Analysis, and Pharmacokinetic Profiling. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35786898/ · DOI 10.1021/acs.jafc.2c02150","model_system":"Human liver/intestinal cytosol, enzyme assignment and a human ingestion pharmacokinetic study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}