Component

Streptococcus mutans glucosyltransferase B / GtfB

Species, exposure, manipulation and limitations are specified on each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Deleting gtfB markedly disrupted S. mutans microcolony formation on saliva-coated hydroxyapatite.

    Streptococcus mutans glucosyltransferase B / GtfB → Streptococcus mutans biofilm microcolony formation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    dose
    Sucrose versus glucose growth conditions; gtfB or gtfB/gtfC deletion
    duration
    Biofilm maturation series; exact dose and duration not recovered from accessed abstract
    evidence_access
    Primary abstract/metadata; unrecovered methods explicitly retained.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    Streptococcus mutans with Streptococcus oralis and Actinomyces naeslundii; gtf mutants
    exposure_scope
    Sucrose-dependent oral bacterial machinery
    limitations
    Bacterial matrix formation and mutant phenotypes; not a clinical caries incidence trial. GtfB and GtfC have different contributions. Only primary abstract and metadata used.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    Streptococcus mutans with Streptococcus oralis and Actinomyces naeslundii; gtf mutants
    plain_language
    Deleting gtfB markedly disrupted S. mutans microcolony formation on saliva-coated hydroxyapatite.
    primary_references
    Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms. (2010). https://pubmed.ncbi.nlm.nih.gov/20233920/ DOI: 10.1128/JB.01649-09
    route
    In vitro bacterial culture
    tissue
    Biofilm on saliva-coated hydroxyapatite
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 415–425

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Streptococcus mutans with Streptococcus oralis and Actinomyces naeslundii; gtf mutants · source_derived_draft · unverified_draft

    ## sucrose-gtfb-deletion Deleting gtfB markedly disrupted S. mutans microcolony formation on saliva-coated hydroxyapatite. Model/species: Streptococcus mutans with Streptococcus oralis and Actinomyces naeslundii; gtf mutants Tissue: Biofilm on saliva-coated hydroxyapatite Exposure: Sucrose versus glucose growth conditions; gtfB or gtfB/gtfC deletion Route: In vitro bacterial culture Duration: Biofilm maturation series; exact dose and duration not recovered from accessed abstract Exposure scope: Sucrose-dependent oral bacterial machinery Limits: Bacterial matrix formation and mutant phenotypes; not a clinical caries incidence trial. GtfB and GtfC have different contributions. Only primary abstract and metadata used. Reference: Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms. (2010). https://pubmed.ncbi.nlm.nih.gov/20233920/ DOI: 10.1128/JB.01649-09 Access: Primary abstract/metadata; unrecovered methods explicitly retained.
    Complete structured claim and evidence

  2. Deleting both gtfB and gtfC produced the greatest reduction in the S. mutans extracellular matrix among the tested mutants.

    Streptococcus mutans glucosyltransferase B / GtfB → Streptococcus mutans extracellular glucan matrix formation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    dose
    Sucrose versus glucose growth conditions; gtfB or gtfB/gtfC deletion
    duration
    Biofilm maturation series; exact dose and duration not recovered from accessed abstract
    evidence_access
    Primary abstract/metadata; unrecovered methods explicitly retained.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    Streptococcus mutans with Streptococcus oralis and Actinomyces naeslundii; gtf mutants
    exposure_scope
    Sucrose-dependent oral bacterial machinery
    limitations
    Bacterial matrix formation and mutant phenotypes; not a clinical caries incidence trial. GtfB and GtfC have different contributions. Only primary abstract and metadata used.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    Streptococcus mutans with Streptococcus oralis and Actinomyces naeslundii; gtf mutants
    plain_language
    Deleting both gtfB and gtfC produced the greatest reduction in the S. mutans extracellular matrix among the tested mutants.
    primary_references
    Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms. (2010). https://pubmed.ncbi.nlm.nih.gov/20233920/ DOI: 10.1128/JB.01649-09
    route
    In vitro bacterial culture
    tissue
    Biofilm on saliva-coated hydroxyapatite
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 427–437

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Streptococcus mutans with Streptococcus oralis and Actinomyces naeslundii; gtf mutants · source_derived_draft · unverified_draft

    ## sucrose-gtfbc-deletion Deleting both gtfB and gtfC produced the greatest reduction in the S. mutans extracellular matrix among the tested mutants. Model/species: Streptococcus mutans with Streptococcus oralis and Actinomyces naeslundii; gtf mutants Tissue: Biofilm on saliva-coated hydroxyapatite Exposure: Sucrose versus glucose growth conditions; gtfB or gtfB/gtfC deletion Route: In vitro bacterial culture Duration: Biofilm maturation series; exact dose and duration not recovered from accessed abstract Exposure scope: Sucrose-dependent oral bacterial machinery Limits: Bacterial matrix formation and mutant phenotypes; not a clinical caries incidence trial. GtfB and GtfC have different contributions. Only primary abstract and metadata used. Reference: Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms. (2010). https://pubmed.ncbi.nlm.nih.gov/20233920/ DOI: 10.1128/JB.01649-09 Access: Primary abstract/metadata; unrecovered methods explicitly retained.
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Sucrose-supported multispecies cultures formed a glucan matrix and structured microcolonies; glucose cultures did not form that matrix under the tested conditions.

    Sucrose → Streptococcus mutans extracellular glucan matrix formation source_derived_draftungraded
    Experimental context and source evidence
    dose
    Sucrose versus glucose growth conditions; gtfB or gtfB/gtfC deletion
    duration
    Biofilm maturation series; exact dose and duration not recovered from accessed abstract
    evidence_access
    Primary abstract/metadata; unrecovered methods explicitly retained.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    Streptococcus mutans with Streptococcus oralis and Actinomyces naeslundii; gtf mutants
    exposure_scope
    Sucrose-dependent oral bacterial machinery
    limitations
    Bacterial matrix formation and mutant phenotypes; not a clinical caries incidence trial. GtfB and GtfC have different contributions. Only primary abstract and metadata used.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    Streptococcus mutans with Streptococcus oralis and Actinomyces naeslundii; gtf mutants
    plain_language
    Sucrose-supported multispecies cultures formed a glucan matrix and structured microcolonies; glucose cultures did not form that matrix under the tested conditions.
    primary_references
    Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms. (2010). https://pubmed.ncbi.nlm.nih.gov/20233920/ DOI: 10.1128/JB.01649-09
    route
    In vitro bacterial culture
    tissue
    Biofilm on saliva-coated hydroxyapatite

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 403–413

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Streptococcus mutans with Streptococcus oralis and Actinomyces naeslundii; gtf mutants · source_derived_draft · unverified_draft

    ## sucrose-biofilm-matrix Sucrose-supported multispecies cultures formed a glucan matrix and structured microcolonies; glucose cultures did not form that matrix under the tested conditions. Model/species: Streptococcus mutans with Streptococcus oralis and Actinomyces naeslundii; gtf mutants Tissue: Biofilm on saliva-coated hydroxyapatite Exposure: Sucrose versus glucose growth conditions; gtfB or gtfB/gtfC deletion Route: In vitro bacterial culture Duration: Biofilm maturation series; exact dose and duration not recovered from accessed abstract Exposure scope: Sucrose-dependent oral bacterial machinery Limits: Bacterial matrix formation and mutant phenotypes; not a clinical caries incidence trial. GtfB and GtfC have different contributions. Only primary abstract and metadata used. Reference: Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms. (2010). https://pubmed.ncbi.nlm.nih.gov/20233920/ DOI: 10.1128/JB.01649-09 Access: Primary abstract/metadata; unrecovered methods explicitly retained.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards