Component
Human STRA8
Human stimulated by retinoic acid 8 protein; transcript induction is recorded as an expression endpoint.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
The same 24-hour RA exposure did not significantly increase SYCP3 or DMC1 RNA in human fetal testis cultures.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Paired cell-culture transcript assay
- exposure
- 14-15 weeks gestation; 1 micromolar RA for 24 h; n=6.
- limitations
- A limited time and marker panel cannot prove permanent failure to enter meiosis.
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Homo sapiens
- plain_language
- STRA8 induction did not activate the full tested meiotic marker panel.
- primary_references
- [human2011] Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad. (2011). https://pubmed.ncbi.nlm.nih.gov/21674038/ DOI: 10.1371/journal.pone.0020249
- tissue_or_cell_type
- human fetal testis
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 343–354
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired cell-culture transcript assay · source_derived_draft · unverified_draft
### va-repro-human-meiotic-panel-boundary The same 24-hour RA exposure did not significantly increase SYCP3 or DMC1 RNA in human fetal testis cultures. Condition category: normal nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: STRA8 induction did not activate the full tested meiotic marker panel. organism: Homo sapiens tissue_or_cell_type: human fetal testis experimental_model: Paired cell-culture transcript assay limitations: A limited time and marker panel cannot prove permanent failure to enter meiosis. exposure: 14-15 weeks gestation; 1 micromolar RA for 24 h; n=6. cross_nutrient: false [human2011] Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad. (2011). https://pubmed.ncbi.nlm.nih.gov/21674038/ DOI: 10.1371/journal.pone.0020249
Complete structured claim and evidenceRA increased STRA8 RNA 2.2-fold in cultured human fetal testis cells.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Disaggregated fetal testis culture
- exposure
- 14-15 weeks gestation; 1 micromolar RA for 24 h; n=5 for STRA8.
- limitations
- This transcript response does not establish entry into meiosis.
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Homo sapiens
- plain_language
- Human fetal testis cells can respond to RA by increasing STRA8.
- primary_references
- [human2011] Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad. (2011). https://pubmed.ncbi.nlm.nih.gov/21674038/ DOI: 10.1371/journal.pone.0020249
- tissue_or_cell_type
- human fetal testis
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 330–341
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Disaggregated fetal testis culture · source_derived_draft · unverified_draft
### va-repro-human-stra8-induction RA increased STRA8 RNA 2.2-fold in cultured human fetal testis cells. Condition category: normal nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: Human fetal testis cells can respond to RA by increasing STRA8. organism: Homo sapiens tissue_or_cell_type: human fetal testis experimental_model: Disaggregated fetal testis culture limitations: This transcript response does not establish entry into meiosis. exposure: 14-15 weeks gestation; 1 micromolar RA for 24 h; n=5 for STRA8. cross_nutrient: false [human2011] Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad. (2011). https://pubmed.ncbi.nlm.nih.gov/21674038/ DOI: 10.1371/journal.pone.0020249
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.