Component
Thiol reversal of garlic-compound SQLE inhibition
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Thiol-containing reagents, including glutathione, prevented or reversed inhibition in the garlic-compound SQLE assay series.
Experimental context and source evidence
- acting_entity
- glutathione
- dose
- SAC IC50 110 micromolar
- duration
- Time-dependent inhibition; duration not retrieved
- evidence_access
- Primary abstract
- experimental_comparison
- SAC and other compounds tested individually; thiol reversal experiments
- experimental_model
- Purified recombinant squalene monooxygenase assay
- interpretation_status
- Source-derived research curation; not independent primary verification
- limitations
- The abstract groups several inhibitors. SAC-specific reversal magnitude and a covalent site are not separately established; dithiols were more effective than monothiols.
- nutrient_topic
- S-allylcysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · S-allyl-L-cysteine / SAC
- organism
- Human recombinant protein
- plain_language
- The enzyme result connects to thiol chemistry.
- primary_references
- [11385050] Garlic and garlic-derived compounds inhibit human squalene monooxygenase. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11385050/ · DOI 10.1093/jn/131.6.1662
- route
- Cell-free enzyme assay
- tissue_or_cell_type
- Purified recombinant squalene monooxygenase assay
S-allylcysteine: sulfur signaling, redox responses and cross-nutrient mechanisms (2026-09-20) · lines 230–237
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Purified recombinant squalene monooxygenase assay · source_derived_draft · unverified_draft
## s-allylcysteine-sqle-thiol-reversal The enzyme result connects to thiol chemistry. Thiol-containing reagents, including glutathione, prevented or reversed inhibition in the garlic-compound SQLE assay series. Model: Purified recombinant squalene monooxygenase assay Limitations: The abstract groups several inhibitors. SAC-specific reversal magnitude and a covalent site are not separately established; dithiols were more effective than monothiols. Evidence access: Primary abstract [11385050] Garlic and garlic-derived compounds inhibit human squalene monooxygenase. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11385050/ · DOI 10.1093/jn/131.6.1662 Structured context: {"organism": "Human recombinant protein", "tissue_or_cell_type": "Purified recombinant squalene monooxygenase assay", "dose": "SAC IC50 110 micromolar", "duration": "Time-dependent inhibition; duration not retrieved", "route": "Cell-free enzyme assay", "experimental_comparison": "SAC and other compounds tested individually; thiol reversal experiments", "acting_entity": "glutathione", "interpretation_status": "Source-derived research curation; not independent primary verification"}
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.