Component
Lesion size after cervical spinal cord injury
Lesion size after cervical spinal cord injury. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
In a rat model of cervical spinal cord injury, dihydrocapsaicin reliably induced systemic cooling to 32 to 33 degrees, and at both 48 hours and 6 weeks the two modes of hypothermia yielded similar improvements in neurological function and lesion size compared with normothermic controls, indicating that dihydrocapsaicin-induced hypothermia may be comparable with physical hypothermia in efficacy but more clinically feasible to administer.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dihydrocapsaicin-research/35675523.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "be32dc3c18b06ec73979a729e98459c00fb147186da0b9601fb1a8e96586fccf", "start_char": 0, "end_char": 1650, "text_sha256": "be32dc3c18b06ec73979a729e98459c00fb147186da0b9601fb1a8e96586fccf"}
- experimental_model
- Blinded rat cervical spinal cord injury study with telemetry and histopathology at 48 hours and 6 weeks
- exposure
- Intravenous dihydrocapsaicin totalling about 0.60 mg/kg begun after a 4 hour delay, against physical cooling, both to 33 degrees for 4 hours
- limitations
- A head-to-head against physical cooling with blinded assessment at two timepoints. It shows equivalence, not superiority, which is what the authors claim.
- nutrient_topic
- Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
- organism
- Rat
- plain_language
- The drug worked about as well as packing the animal in cold fluid, and is easier to give.
- primary_references
- [dhc-p35675523] A Direct Comparison of Physical Versus Dihydrocapsaicin-Induced Hypothermia in a Rat Model of Traumatic Spinal Cord Injury. (2022). https://pubmed.ncbi.nlm.nih.gov/35675523/ DOI: 10.1089/ther.2021.0013
- tissue_or_cell_type
- Cervical spinal cord
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Blinded rat cervical spinal cord injury study with telemetry and histopathology at 48 hours and 6 weeks · source_derived_draft · unverified_draft
### dhc-matches-physical-cooling In a rat model of cervical spinal cord injury, dihydrocapsaicin reliably induced systemic cooling to 32 to 33 degrees, and at both 48 hours and 6 weeks the two modes of hypothermia yielded similar improvements in neurological function and lesion size compared with normothermic controls, indicating that dihydrocapsaicin-induced hypothermia may be comparable with physical hypothermia in efficacy but more clinically feasible to administer. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: The drug worked about as well as packing the animal in cold fluid, and is easier to give. organism: Rat tissue_or_cell_type: Cervical spinal cord experimental_model: Blinded rat cervical spinal cord injury study with telemetry and histopathology at 48 hours and 6 weeks limitations: A head-to-head against physical cooling with blinded assessment at two timepoints. It shows equivalence, not superiority, which is what the authors claim. exposure: Intravenous dihydrocapsaicin totalling about 0.60 mg/kg begun after a 4 hour delay, against physical cooling, both to 33 degrees for 4 hours evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/35675523.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "be32dc3c18b06ec73979a729e98459c00fb147186da0b9601fb1a8e96586fccf", "start_char": 0, "end_char": 1650, "text_sha256": "be32dc3c18b06ec73979a729e98459c00fb147186da0b9601fb1a8e96586fccf"} [dhc-p35675523] A Direct Comparison of Physical Versus Dihydrocapsaicin-Induced Hypothermia in a Rat Model of Traumatic Spinal Cord Injury. (2022). https://pubmed.ncbi.nlm.nih.gov/35675523/ DOI: 10.1089/ther.2021.0013
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.