Component

Spatial memory performance

Spatial memory performance. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The CB1 antagonist SR141716A attenuated the memory impairment produced by THC or by anandamide.

    SR141716A / rimonabant, a CB1 receptor antagonist → Spatial memory performance source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/thc-research/9862397.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "59e00778f9e8b2a2aba64063224de431ef098aaffcf26dca95fd9ddb36981a1f", "start_char": 0, "end_char": 1576, "text_sha256": "59e00778f9e8b2a2aba64063224de431ef098aaffcf26dca95fd9ddb36981a1f"}
    experimental_model
    Memory impairment by THC or anandamide with SR141716A pretreatment
    exposure
    THC or anandamide with a CB1 antagonist
    limitations
    Shows the antagonist rescues the impairment for both the drug and the natural ligand.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Rat
    plain_language
    Blocking the receptor protects the memory, whichever agonist caused the problem.
    primary_references
    [thc-p9862397] The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide. (1998). https://pubmed.ncbi.nlm.nih.gov/9862397/ DOI: 10.1007/s002130050733
    tissue_or_cell_type
    Behaviour
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 452–463

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Memory impairment by THC or anandamide with SR141716A pretreatment · source_derived_draft · unverified_draft

    ### thc-antagonist-rescues-memory The CB1 antagonist SR141716A attenuated the memory impairment produced by THC or by anandamide. Condition category: machinery_impairment nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Blocking the receptor protects the memory, whichever agonist caused the problem. organism: Rat tissue_or_cell_type: Behaviour experimental_model: Memory impairment by THC or anandamide with SR141716A pretreatment limitations: Shows the antagonist rescues the impairment for both the drug and the natural ligand. exposure: THC or anandamide with a CB1 antagonist evidence_span: {"source_cache": "artifacts/thc-research/9862397.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "59e00778f9e8b2a2aba64063224de431ef098aaffcf26dca95fd9ddb36981a1f", "start_char": 0, "end_char": 1576, "text_sha256": "59e00778f9e8b2a2aba64063224de431ef098aaffcf26dca95fd9ddb36981a1f"} [thc-p9862397] The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide. (1998). https://pubmed.ncbi.nlm.nih.gov/9862397/ DOI: 10.1007/s002130050733
    Complete structured claim and evidence

  2. Hippocampal CB1 receptors mediate the memory-impairing effects of THC.

    CB1 receptors in the hippocampus → Spatial memory performance source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/thc-research/19322169.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "30928c5217e21de0bdcdac0c5485e1608c9e1ee354404319a78ee8ac369b9443", "start_char": 0, "end_char": 1794, "text_sha256": "30928c5217e21de0bdcdac0c5485e1608c9e1ee354404319a78ee8ac369b9443"}
    experimental_model
    Region-specific CB1 manipulation with memory testing
    exposure
    THC with hippocampal CB1 manipulation
    limitations
    Localises the effect to one structure, which the whole-animal antagonist studies cannot do.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Rodent
    plain_language
    It is the receptors in one brain structure that account for the memory effect.
    primary_references
    [thc-p19322169] Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol. (2009). https://pubmed.ncbi.nlm.nih.gov/19322169/ DOI: 10.1038/npp.2009.31
    tissue_or_cell_type
    Hippocampus

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 465–476

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Region-specific CB1 manipulation with memory testing · source_derived_draft · unverified_draft

    ### thc-hippocampal-cb1-memory Hippocampal CB1 receptors mediate the memory-impairing effects of THC. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: It is the receptors in one brain structure that account for the memory effect. organism: Rodent tissue_or_cell_type: Hippocampus experimental_model: Region-specific CB1 manipulation with memory testing limitations: Localises the effect to one structure, which the whole-animal antagonist studies cannot do. exposure: THC with hippocampal CB1 manipulation evidence_span: {"source_cache": "artifacts/thc-research/19322169.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "30928c5217e21de0bdcdac0c5485e1608c9e1ee354404319a78ee8ac369b9443", "start_char": 0, "end_char": 1794, "text_sha256": "30928c5217e21de0bdcdac0c5485e1608c9e1ee354404319a78ee8ac369b9443"} [thc-p19322169] Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol. (2009). https://pubmed.ncbi.nlm.nih.gov/19322169/ DOI: 10.1038/npp.2009.31
    Complete structured claim and evidence

  3. THC impaired spatial memory through a cannabinoid receptor mechanism, since the impairment was prevented by receptor blockade.

    Delta-9-tetrahydrocannabinol / THC → Spatial memory performance source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/thc-research/8856831.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cd2ffb6c04147c50bc6a9e311032669fe18406690188a1d058b7e80aa09810e0", "start_char": 0, "end_char": 1652, "text_sha256": "cd2ffb6c04147c50bc6a9e311032669fe18406690188a1d058b7e80aa09810e0"}
    experimental_model
    Spatial memory testing in rats with a CB1 antagonist
    exposure
    THC with antagonist pretreatment
    limitations
    The antagonist arm is what makes this a receptor mechanism rather than a general sedative effect.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Rat
    plain_language
    The memory effect runs through the receptor, not through general sedation.
    primary_references
    [thc-p8856831] Delta 9-tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism. (1996). https://pubmed.ncbi.nlm.nih.gov/8856831/ DOI: 10.1007/bf02246347
    tissue_or_cell_type
    Hippocampus and behaviour

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 439–450

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Spatial memory testing in rats with a CB1 antagonist · source_derived_draft · unverified_draft

    ### thc-thc-spatial-memory THC impaired spatial memory through a cannabinoid receptor mechanism, since the impairment was prevented by receptor blockade. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The memory effect runs through the receptor, not through general sedation. organism: Rat tissue_or_cell_type: Hippocampus and behaviour experimental_model: Spatial memory testing in rats with a CB1 antagonist limitations: The antagonist arm is what makes this a receptor mechanism rather than a general sedative effect. exposure: THC with antagonist pretreatment evidence_span: {"source_cache": "artifacts/thc-research/8856831.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cd2ffb6c04147c50bc6a9e311032669fe18406690188a1d058b7e80aa09810e0", "start_char": 0, "end_char": 1652, "text_sha256": "cd2ffb6c04147c50bc6a9e311032669fe18406690188a1d058b7e80aa09810e0"} [thc-p8856831] Delta 9-tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism. (1996). https://pubmed.ncbi.nlm.nih.gov/8856831/ DOI: 10.1007/bf02246347
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards