{"id":"ce0ab422-4547-56d8-a0dd-f5d77b45a2ac","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-hippocampal-cb1-memory","predicate":"mediates","statement":"Hippocampal CB1 receptors mediate the memory-impairing effects of THC.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"eac9f6b2-6dbd-519e-bcd8-6a6c4d6375bc","mechanism_event_label":"It is the receptors in one brain structure that account for the memory effect.","subject":{"id":"f1c7c5b8-cd02-5e60-afd2-3829549c672f","slug":"hippocampal-cb1","display_name":"CB1 receptors in the hippocampus","entity_type_key":"cellular_process"},"object":{"id":"5f4cf6d2-fb62-592c-b069-c30cd8e87830","slug":"spatial-memory","display_name":"Spatial memory performance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"eac9f6b2-6dbd-519e-bcd8-6a6c4d6375bc","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-hippocampal-cb1-memory-event","event_type":"biochemical_relationship","label":"It is the receptors in one brain structure that account for the memory effect.","description":"Hippocampal CB1 receptors mediate the memory-impairing effects of THC.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5a9e5b75-e6aa-5684-ad62-8a8d60148c84","slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"},"role":"acting_drug","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f1c7c5b8-cd02-5e60-afd2-3829549c672f","slug":"hippocampal-cb1","display_name":"CB1 receptors in the hippocampus","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5f4cf6d2-fb62-592c-b069-c30cd8e87830","slug":"spatial-memory","display_name":"Spatial memory performance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/thc-research/19322169.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"30928c5217e21de0bdcdac0c5485e1608c9e1ee354404319a78ee8ac369b9443\", \"start_char\": 0, \"end_char\": 1794, \"text_sha256\": \"30928c5217e21de0bdcdac0c5485e1608c9e1ee354404319a78ee8ac369b9443\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Region-specific CB1 manipulation with memory testing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"THC with hippocampal CB1 manipulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Localises the effect to one structure, which the whole-animal antagonist studies cannot do.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Rodent","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"It is the receptors in one brain structure that account for the memory effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[thc-p19322169] Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol. (2009). https://pubmed.ncbi.nlm.nih.gov/19322169/ DOI: 10.1038/npp.2009.31","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Hippocampus","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dee8b5e5-e2e7-53ab-9b61-e8412201e83a","evidence_kind":"source_excerpt","locator":"Lines 465-476","start_line":465,"end_line":476,"excerpt":"### thc-hippocampal-cb1-memory\nHippocampal CB1 receptors mediate the memory-impairing effects of THC.\nCondition category: normal\nnutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.\nplain_language: It is the receptors in one brain structure that account for the memory effect.\norganism: Rodent\ntissue_or_cell_type: Hippocampus\nexperimental_model: Region-specific CB1 manipulation with memory testing\nlimitations: Localises the effect to one structure, which the whole-animal antagonist studies cannot do.\nexposure: THC with hippocampal CB1 manipulation\nevidence_span: {\"source_cache\": \"artifacts/thc-research/19322169.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"30928c5217e21de0bdcdac0c5485e1608c9e1ee354404319a78ee8ac369b9443\", \"start_char\": 0, \"end_char\": 1794, \"text_sha256\": \"30928c5217e21de0bdcdac0c5485e1608c9e1ee354404319a78ee8ac369b9443\"}\n[thc-p19322169] Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol. (2009). https://pubmed.ncbi.nlm.nih.gov/19322169/ DOI: 10.1038/npp.2009.31","model_system":"Region-specific CB1 manipulation with memory testing","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [thc-p19322169] Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol. (2009). https://pubmed.ncbi.nlm.nih.gov/19322169/ DOI: 10.1038/npp.2009.31","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b4367320-9724-507a-bead-6932fa0a78cb","stable_key":"import-05a3cf47-e660-5ab3-8c32-5eba9847cf0a","title":"THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"60abc81737d18b7a50b01ca487e38291774ee15d9777651aa2d3eac8670ac3b2","revision_id":"2cba3552-af89-580d-b20a-8cfb1b14f9e7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}