Component
Patient-reported sleep-related daytime impairment
Patient-reported sleep-related daytime impairment. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Patient-reported sleep-related impairment improved compared with placebo plus scheduling.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/melatonin-research/29912983.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c", "start_char": 0, "end_char": 3360, "text_sha256": "fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c"}
- experimental_model
- Randomized double-blind placebo-controlled trial
- exposure
- 0.5 mg fast-release one hour before desired bedtime, plus behavioral scheduling in both arms, four weeks
- limitations
- Selected delayed-phase population, not all people reporting insomnia. Post-treatment DLMO subset did not differ significantly; long-term effects were not tested.
- nutrient_topic
- Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
- organism
- 116 people with delayed sleep-wake phase disorder and delayed endogenous phase
- plain_language
- The trial measured daytime consequences as well as sleep onset.
- primary_references
- [melatonin-p29912983] Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial. (2018). https://pubmed.ncbi.nlm.nih.gov/29912983/ DOI: 10.1371/journal.pmed.1002587
- tissue_or_cell_type
- Sleep timing and daytime impairment
Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 942–953
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial · source_derived_draft · unverified_draft
### melatonin-dswpd-daytime Patient-reported sleep-related impairment improved compared with placebo plus scheduling. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The trial measured daytime consequences as well as sleep onset. organism: 116 people with delayed sleep-wake phase disorder and delayed endogenous phase tissue_or_cell_type: Sleep timing and daytime impairment experimental_model: Randomized double-blind placebo-controlled trial limitations: Selected delayed-phase population, not all people reporting insomnia. Post-treatment DLMO subset did not differ significantly; long-term effects were not tested. exposure: 0.5 mg fast-release one hour before desired bedtime, plus behavioral scheduling in both arms, four weeks evidence_span: {"source_cache": "artifacts/melatonin-research/29912983.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c", "start_char": 0, "end_char": 3360, "text_sha256": "fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c"} [melatonin-p29912983] Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial. (2018). https://pubmed.ncbi.nlm.nih.gov/29912983/ DOI: 10.1371/journal.pmed.1002587
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.