{"id":"f2a15b80-d340-538c-b159-7867b26386d4","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-dswpd-daytime","predicate":"reduces_with_behavioral_schedule","statement":"Patient-reported sleep-related impairment improved compared with placebo plus scheduling.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d19b6243-d918-50b4-9dbb-eddf0884ca9f","mechanism_event_label":"The trial measured daytime consequences as well as sleep onset.","subject":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"object":{"id":"02091a4f-a8a5-5a37-817f-afad49bfad69","slug":"sleep-related-daytime-impairment","display_name":"Patient-reported sleep-related daytime impairment","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d19b6243-d918-50b4-9dbb-eddf0884ca9f","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-dswpd-daytime-event","event_type":"observed_intervention","label":"The trial measured daytime consequences as well as sleep onset.","description":"Patient-reported sleep-related impairment improved compared with placebo plus scheduling.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"02091a4f-a8a5-5a37-817f-afad49bfad69","slug":"sleep-related-daytime-impairment","display_name":"Patient-reported sleep-related daytime impairment","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/29912983.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c\", \"start_char\": 0, \"end_char\": 3360, \"text_sha256\": \"fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"0.5 mg fast-release one hour before desired bedtime, plus behavioral scheduling in both arms, four weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Selected delayed-phase population, not all people reporting insomnia. Post-treatment DLMO subset did not differ significantly; long-term effects were not tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"116 people with delayed sleep-wake phase disorder and delayed endogenous phase","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The trial measured daytime consequences as well as sleep onset.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p29912983] Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial. (2018). https://pubmed.ncbi.nlm.nih.gov/29912983/ DOI: 10.1371/journal.pmed.1002587","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Sleep timing and daytime impairment","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"70d9f924-08dd-5df0-8b0b-1f65d2cc6909","evidence_kind":"source_excerpt","locator":"Lines 942-953","start_line":942,"end_line":953,"excerpt":"### melatonin-dswpd-daytime\nPatient-reported sleep-related impairment improved compared with placebo plus scheduling.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The trial measured daytime consequences as well as sleep onset.\norganism: 116 people with delayed sleep-wake phase disorder and delayed endogenous phase\ntissue_or_cell_type: Sleep timing and daytime impairment\nexperimental_model: Randomized double-blind placebo-controlled trial\nlimitations: Selected delayed-phase population, not all people reporting insomnia. Post-treatment DLMO subset did not differ significantly; long-term effects were not tested.\nexposure: 0.5 mg fast-release one hour before desired bedtime, plus behavioral scheduling in both arms, four weeks\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/29912983.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c\", \"start_char\": 0, \"end_char\": 3360, \"text_sha256\": \"fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c\"}\n[melatonin-p29912983] Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial. 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