Component
Brain phosphate and pH measurements during sleep deprivation
Brain phosphate and pH measurements during sleep deprivation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Creatine altered PCr/Pi, ATP and total-creatine/total-NAA measures and prevented the observed fall in brain pH during sleep deprivation.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/creatine-research/38418482.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b6dad9388eb7cb8986f1873e6ba9f8dd36924c7a9aa7c661059cde1012f1e3a8", "start_char": 0, "end_char": 1364, "text_sha256": "b6dad9388eb7cb8986f1873e6ba9f8dd36924c7a9aa7c661059cde1012f1e3a8"}
- experimental_model
- Placebo comparison with repeated phosphorus/proton MRS and cognition
- exposure
- Single creatine monohydrate dose 0.35 g/kg during approximately 21 hours of sleep deprivation
- limitations
- Acute high-dose, sleep-deprivation setting; not an everyday dose recommendation or proof of benefit in well-rested people.
- nutrient_topic
- Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
- organism
- Human participants during sleep deprivation
- plain_language
- The experiment detected changes in brain energy-related measurements under acute sleep stress.
- primary_references
- [creatine-p38418482] Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. (2024). https://pubmed.ncbi.nlm.nih.gov/38418482/ DOI: 10.1038/s41598-024-54249-9
- tissue_or_cell_type
- Brain spectroscopy and cognitive performance
Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 1049–1060
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Placebo comparison with repeated phosphorus/proton MRS and cognition · source_derived_draft · unverified_draft
### creatine-sleep-deprivation-phosphates Creatine altered PCr/Pi, ATP and total-creatine/total-NAA measures and prevented the observed fall in brain pH during sleep deprivation. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The experiment detected changes in brain energy-related measurements under acute sleep stress. organism: Human participants during sleep deprivation tissue_or_cell_type: Brain spectroscopy and cognitive performance experimental_model: Placebo comparison with repeated phosphorus/proton MRS and cognition limitations: Acute high-dose, sleep-deprivation setting; not an everyday dose recommendation or proof of benefit in well-rested people. exposure: Single creatine monohydrate dose 0.35 g/kg during approximately 21 hours of sleep deprivation evidence_span: {"source_cache": "artifacts/creatine-research/38418482.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b6dad9388eb7cb8986f1873e6ba9f8dd36924c7a9aa7c661059cde1012f1e3a8", "start_char": 0, "end_char": 1364, "text_sha256": "b6dad9388eb7cb8986f1873e6ba9f8dd36924c7a9aa7c661059cde1012f1e3a8"} [creatine-p38418482] Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. (2024). https://pubmed.ncbi.nlm.nih.gov/38418482/ DOI: 10.1038/s41598-024-54249-9
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.