Component
SLC4A11-associated proton conductance
SLC4A11-associated proton conductance. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The 2024 study supported NH4Cl-induced allosteric activation of human SLC4A11 proton conductance through an acidic shift in its intracellular-pH dependence.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/boron-research/39206384.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c27f8cf16ff99f2c01490828570d4ed7e71ca07290e31c70218917ea285b5df9", "start_char": 0, "end_char": 1152, "text_sha256": "c27f8cf16ff99f2c01490828570d4ed7e71ca07290e31c70218917ea285b5df9"}
- experimental_model
- Human SLC4A11 electrophysiology and intracellular-pH analysis
- exposure
- NH4Cl and extracellular/intracellular pH manipulations
- limitations
- Supports an allosteric proton-conductance model; ammonia cotransport versus indirect activation remains debated. This is not evidence of boron transport.
- nutrient_topic
- Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
- organism
- Human protein in Xenopus oocytes
- plain_language
- The protein has experimentally supported roles in proton handling; its old borate-transporter name is not proof that it carries boron.
- primary_references
- [boron-p39206384] NH3/NH4 + allosterically activates SLC4A11 by causing an acidic shift in the intracellular pK that governs H+(OH-) conductance. (2024). https://pubmed.ncbi.nlm.nih.gov/39206384/ DOI: 10.3389/fphys.2024.1440720
- tissue_or_cell_type
- Heterologous membrane
Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 235–246
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human SLC4A11 electrophysiology and intracellular-pH analysis · source_derived_draft · unverified_draft
### boron-human-proton-conductance The 2024 study supported NH4Cl-induced allosteric activation of human SLC4A11 proton conductance through an acidic shift in its intracellular-pH dependence. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The protein has experimentally supported roles in proton handling; its old borate-transporter name is not proof that it carries boron. organism: Human protein in Xenopus oocytes tissue_or_cell_type: Heterologous membrane experimental_model: Human SLC4A11 electrophysiology and intracellular-pH analysis limitations: Supports an allosteric proton-conductance model; ammonia cotransport versus indirect activation remains debated. This is not evidence of boron transport. exposure: NH4Cl and extracellular/intracellular pH manipulations evidence_span: {"source_cache": "artifacts/boron-research/39206384.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c27f8cf16ff99f2c01490828570d4ed7e71ca07290e31c70218917ea285b5df9", "start_char": 0, "end_char": 1152, "text_sha256": "c27f8cf16ff99f2c01490828570d4ed7e71ca07290e31c70218917ea285b5df9"} [boron-p39206384] NH3/NH4 + allosterically activates SLC4A11 by causing an acidic shift in the intracellular pK that governs H+(OH-) conductance. (2024). https://pubmed.ncbi.nlm.nih.gov/39206384/ DOI: 10.3389/fphys.2024.1440720
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.