{"id":"451529c4-648a-5297-b31d-d3950bc7c247","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-human-proton-conductance","predicate":"mediates","statement":"The 2024 study supported NH4Cl-induced allosteric activation of human SLC4A11 proton conductance through an acidic shift in its intracellular-pH dependence.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"105f90a6-60fe-5053-b618-9a24b560d910","mechanism_event_label":"The protein has experimentally supported roles in proton handling; its old borate-transporter name is not proof that it carries boron.","subject":{"id":"85fea21a-9b03-5b27-9588-e716d8390743","slug":"slc4a11","display_name":"Human SLC4A11 / NaBC1","entity_type_key":"protein"},"object":{"id":"4a8b8bb2-05ae-5563-9c18-40d25ec0e0e9","slug":"slc4a11-proton-conductance","display_name":"SLC4A11-associated proton conductance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"105f90a6-60fe-5053-b618-9a24b560d910","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-human-proton-conductance-event","event_type":"biochemical_relationship","label":"The protein has experimentally supported roles in proton handling; its old borate-transporter name is not proof that it carries boron.","description":"The 2024 study supported NH4Cl-induced allosteric activation of human SLC4A11 proton conductance through an acidic shift in its intracellular-pH dependence.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"85fea21a-9b03-5b27-9588-e716d8390743","slug":"slc4a11","display_name":"Human SLC4A11 / NaBC1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4a8b8bb2-05ae-5563-9c18-40d25ec0e0e9","slug":"slc4a11-proton-conductance","display_name":"SLC4A11-associated proton conductance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/39206384.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c27f8cf16ff99f2c01490828570d4ed7e71ca07290e31c70218917ea285b5df9\", \"start_char\": 0, \"end_char\": 1152, \"text_sha256\": \"c27f8cf16ff99f2c01490828570d4ed7e71ca07290e31c70218917ea285b5df9\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human SLC4A11 electrophysiology and intracellular-pH analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"NH4Cl and extracellular/intracellular pH manipulations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Supports an allosteric proton-conductance model; ammonia cotransport versus indirect activation remains debated. This is not evidence of boron transport.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human protein in Xenopus oocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The protein has experimentally supported roles in proton handling; its old borate-transporter name is not proof that it carries boron.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p39206384] NH3/NH4 + allosterically activates SLC4A11 by causing an acidic shift in the intracellular pK that governs H+(OH-) conductance. (2024). https://pubmed.ncbi.nlm.nih.gov/39206384/ DOI: 10.3389/fphys.2024.1440720","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Heterologous membrane","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"47b3b596-fddd-5a4a-98f2-46674961dc05","evidence_kind":"source_excerpt","locator":"Lines 235-246","start_line":235,"end_line":246,"excerpt":"### boron-human-proton-conductance\nThe 2024 study supported NH4Cl-induced allosteric activation of human SLC4A11 proton conductance through an acidic shift in its intracellular-pH dependence.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The protein has experimentally supported roles in proton handling; its old borate-transporter name is not proof that it carries boron.\norganism: Human protein in Xenopus oocytes\ntissue_or_cell_type: Heterologous membrane\nexperimental_model: Human SLC4A11 electrophysiology and intracellular-pH analysis\nlimitations: Supports an allosteric proton-conductance model; ammonia cotransport versus indirect activation remains debated. This is not evidence of boron transport.\nexposure: NH4Cl and extracellular/intracellular pH manipulations\nevidence_span: {\"source_cache\": \"artifacts/boron-research/39206384.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c27f8cf16ff99f2c01490828570d4ed7e71ca07290e31c70218917ea285b5df9\", \"start_char\": 0, \"end_char\": 1152, \"text_sha256\": \"c27f8cf16ff99f2c01490828570d4ed7e71ca07290e31c70218917ea285b5df9\"}\n[boron-p39206384] NH3/NH4 + allosterically activates SLC4A11 by causing an acidic shift in the intracellular pK that governs H+(OH-) conductance. (2024). https://pubmed.ncbi.nlm.nih.gov/39206384/ DOI: 10.3389/fphys.2024.1440720","model_system":"Human SLC4A11 electrophysiology and intracellular-pH analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p39206384] NH3/NH4 + allosterically activates SLC4A11 by causing an acidic shift in the intracellular pK that governs H+(OH-) conductance. (2024). https://pubmed.ncbi.nlm.nih.gov/39206384/ DOI: 10.3389/fphys.2024.1440720","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"0a32c1c5c70cfb4a378f6ace35cf5b75d90ed3065ada91b9f9f64015d603c8e3","revision_id":"38f316f2-4344-542e-a638-0ac5402f678d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}