Component
Human erythrocyte anion exchanger 1 / SLC4A1
Human erythrocyte anion exchanger 1 / SLC4A1. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
DIDS inhibited the intracellular thiol decrease and extracellular increase during vanadate exposure, supporting an anion-transport-dependent step.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Human erythrocytes; DIDS pharmacological intervention.
- limitations
- DIDS is an inhibitor, not itself an exchanger; pharmacology does not establish a unique SLC4A1 transport substrate or route.
- nutrient_topic
- Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Vanadium
- plain_language
- Membrane transport can gate the redox response.
- primary_references
- Efflux of glutathione and glutathione complexes from human erythrocytes in response to vanadate. · 2013 · https://pubmed.ncbi.nlm.nih.gov/22824382/ · DOI 10.1016/j.bcmd.2012.07.001
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19) · lines 166–172
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human erythrocytes; DIDS pharmacological intervention. · source_derived_draft · unverified_draft
## vanadium-anion-exchanger-block Membrane transport can gate the redox response. DIDS inhibited the intracellular thiol decrease and extracellular increase during vanadate exposure, supporting an anion-transport-dependent step. Model: Human erythrocytes; DIDS pharmacological intervention. Limitations: DIDS is an inhibitor, not itself an exchanger; pharmacology does not establish a unique SLC4A1 transport substrate or route. Evidence access: Primary abstract Efflux of glutathione and glutathione complexes from human erythrocytes in response to vanadate. · 2013 · https://pubmed.ncbi.nlm.nih.gov/22824382/ · DOI 10.1016/j.bcmd.2012.07.001
Complete structured claim and evidenceCryo-EM resolved bicarbonate-bound human AE1 and identified substrate-recognition features.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chloride-research/37679563.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8330a7df77cf5fed0d32a5623d7e0531cacb4306d3e4356b4fcbdb591501d3ef", "start_char": 0, "end_char": 1012, "text_sha256": "8330a7df77cf5fed0d32a5623d7e0531cacb4306d3e4356b4fcbdb591501d3ef"}
- experimental_model
- Seven cryo-EM structures with uptake and computational analyses
- exposure
- Apo, bicarbonate-bound and inhibitor-bound states
- limitations
- Transport mechanism analysis; not a dietary chloride threshold.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- Human AE1
- plain_language
- Red cells use a dedicated anion exchanger in the system that carries carbon dioxide between tissues and lungs.
- primary_references
- [chloride-p37679563] Substrate binding and inhibition of the anion exchanger 1 transporter. (2023). https://pubmed.ncbi.nlm.nih.gov/37679563/ DOI: 10.1038/s41594-023-01085-6
- tissue_or_cell_type
- Erythrocyte anion exchanger protein
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 302–313
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Seven cryo-EM structures with uptake and computational analyses · source_derived_draft · unverified_draft
### chloride-ae1-bicarbonate Cryo-EM resolved bicarbonate-bound human AE1 and identified substrate-recognition features. Condition category: normal nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: Red cells use a dedicated anion exchanger in the system that carries carbon dioxide between tissues and lungs. organism: Human AE1 tissue_or_cell_type: Erythrocyte anion exchanger protein experimental_model: Seven cryo-EM structures with uptake and computational analyses limitations: Transport mechanism analysis; not a dietary chloride threshold. exposure: Apo, bicarbonate-bound and inhibitor-bound states evidence_span: {"source_cache": "artifacts/chloride-research/37679563.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8330a7df77cf5fed0d32a5623d7e0531cacb4306d3e4356b4fcbdb591501d3ef", "start_char": 0, "end_char": 1012, "text_sha256": "8330a7df77cf5fed0d32a5623d7e0531cacb4306d3e4356b4fcbdb591501d3ef"} [chloride-p37679563] Substrate binding and inhibition of the anion exchanger 1 transporter. (2023). https://pubmed.ncbi.nlm.nih.gov/37679563/ DOI: 10.1038/s41594-023-01085-6
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.