Component
Human SLC44A4 isoform 3
634-residue hTPPT-3 tested in the 2014 study; transcript NM_001178045.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Expressed SLC44A4 isoform 3 also supported ThDP uptake.
Experimental context and source evidence
- evidence-scope
- ARPE19; MDCK; human colon
- evidence_locator
- Figure 10
- evidence_spans
- [{"source_document": "artifacts/thiamine_transport_sources/PMC3924303.txt", "start_char": 39610, "end_char": 40292}]
- experimental_model
- Human SLC44A4 isoforms expressed in ARPE19 cells; polarized MDCK imaging.
- limitations
- Not evidence for untested isoform 2.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Human constructs; human and canine host cells
- plain_language
- A second splice form retained transport activity.
- primary_references
- [nabokina-2014-slc44a4] Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC3924303/ DOI: 10.1074/jbc.M113.528257
- tissue_or_cell_type
- ARPE19; MDCK; human colon
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 531–543
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human SLC44A4 isoforms expressed in ARPE19 cells; polarized MDCK imaging. · source_derived_draft · unverified_draft
### b1-slc44a4-iso3-uptake Expressed SLC44A4 isoform 3 also supported ThDP uptake. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A second splice form retained transport activity. organism: Human constructs; human and canine host cells tissue_or_cell_type: ARPE19; MDCK; human colon experimental_model: Human SLC44A4 isoforms expressed in ARPE19 cells; polarized MDCK imaging. limitations: Not evidence for untested isoform 2. evidence_locator: Figure 10 evidence_spans: [{"source_document": "artifacts/thiamine_transport_sources/PMC3924303.txt", "start_char": 39610, "end_char": 40292}] evidence-scope: ARPE19; MDCK; human colon [nabokina-2014-slc44a4] Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC3924303/ DOI: 10.1074/jbc.M113.528257
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.