Component

Human SLC44A4 thiamine diphosphate transporter

Human transporter with experimentally characterized colonic thiamine diphosphate uptake.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Human SLC44A4 isoform 1 expression increased ThDP uptake in ARPE19 cells.

    Human SLC44A4 isoform 1 → Colonic thiamine diphosphate uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence-scope
    ARPE19; MDCK; human colon
    evidence_locator
    Figure 1
    evidence_spans
    [{"source_document": "artifacts/thiamine_transport_sources/PMC3924303.txt", "start_char": 19781, "end_char": 21596}]
    experimental_model
    Human SLC44A4 isoforms expressed in ARPE19 cells; polarized MDCK imaging.
    limitations
    Heterologous uptake; host dietary contribution unmeasured.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Human constructs; human and canine host cells
    plain_language
    This SLC44A4 form can carry phosphorylated B1.
    primary_references
    [nabokina-2014-slc44a4] Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC3924303/ DOI: 10.1074/jbc.M113.528257
    tissue_or_cell_type
    ARPE19; MDCK; human colon

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 517–529

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human SLC44A4 isoforms expressed in ARPE19 cells; polarized MDCK imaging. · source_derived_draft · unverified_draft

    ### b1-slc44a4-iso1-uptake Human SLC44A4 isoform 1 expression increased ThDP uptake in ARPE19 cells. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: This SLC44A4 form can carry phosphorylated B1. organism: Human constructs; human and canine host cells tissue_or_cell_type: ARPE19; MDCK; human colon experimental_model: Human SLC44A4 isoforms expressed in ARPE19 cells; polarized MDCK imaging. limitations: Heterologous uptake; host dietary contribution unmeasured. evidence_locator: Figure 1 evidence_spans: [{"source_document": "artifacts/thiamine_transport_sources/PMC3924303.txt", "start_char": 19781, "end_char": 21596}] evidence-scope: ARPE19; MDCK; human colon [nabokina-2014-slc44a4] Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC3924303/ DOI: 10.1074/jbc.M113.528257
    Complete structured claim and evidence

  2. Expressed SLC44A4 isoform 3 also supported ThDP uptake.

    Human SLC44A4 isoform 3 → Colonic thiamine diphosphate uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence-scope
    ARPE19; MDCK; human colon
    evidence_locator
    Figure 10
    evidence_spans
    [{"source_document": "artifacts/thiamine_transport_sources/PMC3924303.txt", "start_char": 39610, "end_char": 40292}]
    experimental_model
    Human SLC44A4 isoforms expressed in ARPE19 cells; polarized MDCK imaging.
    limitations
    Not evidence for untested isoform 2.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Human constructs; human and canine host cells
    plain_language
    A second splice form retained transport activity.
    primary_references
    [nabokina-2014-slc44a4] Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC3924303/ DOI: 10.1074/jbc.M113.528257
    tissue_or_cell_type
    ARPE19; MDCK; human colon

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 531–543

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human SLC44A4 isoforms expressed in ARPE19 cells; polarized MDCK imaging. · source_derived_draft · unverified_draft

    ### b1-slc44a4-iso3-uptake Expressed SLC44A4 isoform 3 also supported ThDP uptake. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A second splice form retained transport activity. organism: Human constructs; human and canine host cells tissue_or_cell_type: ARPE19; MDCK; human colon experimental_model: Human SLC44A4 isoforms expressed in ARPE19 cells; polarized MDCK imaging. limitations: Not evidence for untested isoform 2. evidence_locator: Figure 10 evidence_spans: [{"source_document": "artifacts/thiamine_transport_sources/PMC3924303.txt", "start_char": 39610, "end_char": 40292}] evidence-scope: ARPE19; MDCK; human colon [nabokina-2014-slc44a4] Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC3924303/ DOI: 10.1074/jbc.M113.528257
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards