Component
SLC30A10 divalent-metal transport selectivity
Comparative transport of Mn(II), Zn(II), Ca(II) and Mg(II) in the reconstituted transporter assay.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Reconstituted human SLC30A10 transported Mn(II), while the same study detected no significant Zn(II), Ca(II) or Mg(II) transport under its tested conditions.
Experimental context and source evidence
- cross_nutrient
- true
- experimental_model
- Purified full-length human SLC30A10 reconstituted into liposomes; Figure 1f and Supplementary Figure 3e-g
- exposure
- Separate MnCl2, ZnCl2, CaCl2 and MgCl2 proteoliposome transport tests.
- limitations
- The negative results are assay-bounded; they do not rule out calcium coupling under other gradients, establish exchange stoichiometry, or define a nutritional threshold.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Human protein
- plain_language
- The purified transporter carried manganese without measurable transport of the three comparison metals in this assay.
- primary_references
- [mn-trans-41022720] Molecular mechanisms of SLC30A10-mediated manganese transport. (2025). https://pubmed.ncbi.nlm.nih.gov/41022720/ DOI: 10.1038/s41467-025-63616-7
- tissue_or_cell_type
- Proteoliposomes
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 396–407
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified full-length human SLC30A10 reconstituted into liposomes; Figure 1f and Supplementary Figure 3e-g · source_derived_draft · unverified_draft
### mn-trans-slc30a10-metal-selectivity Reconstituted human SLC30A10 transported Mn(II), while the same study detected no significant Zn(II), Ca(II) or Mg(II) transport under its tested conditions. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The purified transporter carried manganese without measurable transport of the three comparison metals in this assay. organism: Human protein tissue_or_cell_type: Proteoliposomes experimental_model: Purified full-length human SLC30A10 reconstituted into liposomes; Figure 1f and Supplementary Figure 3e-g limitations: The negative results are assay-bounded; they do not rule out calcium coupling under other gradients, establish exchange stoichiometry, or define a nutritional threshold. exposure: Separate MnCl2, ZnCl2, CaCl2 and MgCl2 proteoliposome transport tests. cross_nutrient: true [mn-trans-41022720] Molecular mechanisms of SLC30A10-mediated manganese transport. (2025). https://pubmed.ncbi.nlm.nih.gov/41022720/ DOI: 10.1038/s41467-025-63616-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.