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(2025). https://pubmed.ncbi.nlm.nih.gov/41022720/ DOI: 10.1038/s41467-025-63616-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Proteoliposomes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"14911fca-72a2-5655-a382-98dadebe33ec","evidence_kind":"source_excerpt","locator":"Lines 396-407","start_line":396,"end_line":407,"excerpt":"### mn-trans-slc30a10-metal-selectivity\nReconstituted human SLC30A10 transported Mn(II), while the same study detected no significant Zn(II), Ca(II) or Mg(II) transport under its tested conditions.\nCondition category: normal\nnutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The purified transporter carried manganese without measurable transport of the three comparison metals in this assay.\norganism: Human protein\ntissue_or_cell_type: Proteoliposomes\nexperimental_model: Purified full-length human SLC30A10 reconstituted into liposomes; Figure 1f and Supplementary Figure 3e-g\nlimitations: The negative results are assay-bounded; they do not rule out calcium coupling under other gradients, establish exchange stoichiometry, or define a nutritional threshold.\nexposure: Separate MnCl2, ZnCl2, CaCl2 and MgCl2 proteoliposome transport tests.\ncross_nutrient: true\n[mn-trans-41022720] Molecular mechanisms of SLC30A10-mediated manganese transport. 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