Component
Human SLC30A10 D40A mutant
Asp40-to-Ala substitution in the human SLC30A10 transporter; distinct from wild-type SLC30A10.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human SLC30A10 D40A lost manganese transport function in the HEK293T assay compared with wild-type SLC30A10.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Site-directed SLC30A10 mutagenesis in HEK293T cells
- exposure
- D40A versus wild-type human SLC30A10 expression in HEK293T cells.
- limitations
- The functional mutant comparison does not establish treatment efficacy or a dietary manganese deficiency.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Homo sapiens
- plain_language
- Changing aspartate 40 to alanine disabled the measured manganese transport function.
- primary_references
- [mn-trans-41022720] Molecular mechanisms of SLC30A10-mediated manganese transport. (2025). https://pubmed.ncbi.nlm.nih.gov/41022720/ DOI: 10.1038/s41467-025-63616-7
- tissue_or_cell_type
- HEK293T cellular manganese handling
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 409–420
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Site-directed SLC30A10 mutagenesis in HEK293T cells · source_derived_draft · unverified_draft
### mn-trans-slc30a10-d40a-transport-loss Human SLC30A10 D40A lost manganese transport function in the HEK293T assay compared with wild-type SLC30A10. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Changing aspartate 40 to alanine disabled the measured manganese transport function. organism: Homo sapiens tissue_or_cell_type: HEK293T cellular manganese handling experimental_model: Site-directed SLC30A10 mutagenesis in HEK293T cells limitations: The functional mutant comparison does not establish treatment efficacy or a dietary manganese deficiency. exposure: D40A versus wild-type human SLC30A10 expression in HEK293T cells. cross_nutrient: false [mn-trans-41022720] Molecular mechanisms of SLC30A10-mediated manganese transport. (2025). https://pubmed.ncbi.nlm.nih.gov/41022720/ DOI: 10.1038/s41467-025-63616-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.