Component
Human fructose transporter GLUT5 / SLC2A5
Species, exposure, manipulation and evidence limits are specified on each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Expressed human GLUT5 selectively transported fructose, with a reported Km near 6 mM.
Experimental context and source evidence
- dose
- Fructose kinetic series; reported Km about 6 mM
- duration
- Assay interval unavailable in abstract
- evidence_access
- Primary abstract/metadata; unrecovered methods explicitly retained.
- evidence_scope
- literature_reviewed; source-specific curation
- experimental_model
- Human GLUT5 expressed in Xenopus oocytes
- exposure_scope
- Isolated fructose / human protein
- limitations
- Human protein in an amphibian expression system; not a measured human intake threshold.
- nutrient_topic
- HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished. · High-Fructose Corn Syrup / HFCS
- organism
- Human GLUT5 expressed in Xenopus oocytes
- plain_language
- Expressed human GLUT5 selectively transported fructose, with a reported Km near 6 mM.
- primary_references
- Fructose transporter in human spermatozoa and small intestine is GLUT5. (1992). https://pubmed.ncbi.nlm.nih.gov/1634504/
- route
- In vitro substrate addition
- tissue
- Recombinant transport assay
- transport_effect
- raises Fructose uptake measured in the expressing cell with a reported Km near 6 mM.
- transport_pool
- the expressing cell Fructose uptake measured in the expressing cell with a reported Km near 6 mM.
High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20) · lines 65–75
Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Human GLUT5 expressed in Xenopus oocytes · source_derived_draft · unverified_draft
## hfcs-glut5 Expressed human GLUT5 selectively transported fructose, with a reported Km near 6 mM. Model/species: Human GLUT5 expressed in Xenopus oocytes Tissue: Recombinant transport assay Exposure: Fructose kinetic series; reported Km about 6 mM Route: In vitro substrate addition Duration: Assay interval unavailable in abstract Exposure scope: Isolated fructose / human protein Limits: Human protein in an amphibian expression system; not a measured human intake threshold. Reference: Fructose transporter in human spermatozoa and small intestine is GLUT5. (1992). https://pubmed.ncbi.nlm.nih.gov/1634504/ Access: Primary abstract/metadata; unrecovered methods explicitly retained.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.