Human mitochondrial choline carrier SLC25A48: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

Human-cell experiments identified SLC25A48 as necessary for efficient mitochondrial choline import.
Human mitochondrial choline carrier SLC25A48 → Human mitochondrial choline import source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/choline-research/39111307.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c0a9377732782bdaa55105cae0a0446afcfb1225e686d2b047a7fdf1ef67535f", "start_char": 0, "end_char": 1201, "text_sha256": "c0a9377732782bdaa55105cae0a0446afcfb1225e686d2b047a7fdf1ef67535f"}
experimental_model
Slc25a48 knockout, rescue, mitochondrial assays and isotope tracing
exposure
Germline mouse knockout; human-cell SLC25A48 loss; labeled choline
limitations
Transport, energy and one-carbon outcomes are model-specific; normal intake cannot be assumed to correct a carrier defect.
nutrient_topic
Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
organism
Human HEK293T cells
plain_language
Choline must cross another membrane to reach its mitochondrial metabolic route.
primary_references
[choline-p39111307] SLC25A48 controls mitochondrial choline import and metabolism. (2024). https://pubmed.ncbi.nlm.nih.gov/39111307/ DOI: 10.1016/j.cmet.2024.07.010
tissue_or_cell_type
Brown adipose tissue and human HEK293T cells
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 477–488
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Slc25a48 knockout, rescue, mitochondrial assays and isotope tracing · source_derived_draft · unverified_draft
### choline-slc25a48-import Human-cell experiments identified SLC25A48 as necessary for efficient mitochondrial choline import. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Choline must cross another membrane to reach its mitochondrial metabolic route. organism: Human HEK293T cells tissue_or_cell_type: Brown adipose tissue and human HEK293T cells experimental_model: Slc25a48 knockout, rescue, mitochondrial assays and isotope tracing limitations: Transport, energy and one-carbon outcomes are model-specific; normal intake cannot be assumed to correct a carrier defect. exposure: Germline mouse knockout; human-cell SLC25A48 loss; labeled choline evidence_span: {"source_cache": "artifacts/choline-research/39111307.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c0a9377732782bdaa55105cae0a0446afcfb1225e686d2b047a7fdf1ef67535f", "start_char": 0, "end_char": 1201, "text_sha256": "c0a9377732782bdaa55105cae0a0446afcfb1225e686d2b047a7fdf1ef67535f"} [choline-p39111307] SLC25A48 controls mitochondrial choline import and metabolism. (2024). https://pubmed.ncbi.nlm.nih.gov/39111307/ DOI: 10.1016/j.cmet.2024.07.010
Complete structured claim and evidence
An independent GeneMAP study found that SLC25A48 loss strongly impaired mitochondrial choline import.
Human mitochondrial choline carrier SLC25A48 → Human mitochondrial choline import source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/choline-research/38977856.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "80a5e7038c33442cc887901558cb662b39fe4c54e3821f860c12a388c8a44c92", "start_char": 0, "end_char": 1169, "text_sha256": "80a5e7038c33442cc887901558cb662b39fe4c54e3821f860c12a388c8a44c92"}
experimental_model
Independent gene–metabolite mapping and mitochondrial experiments
exposure
SLC25A48 genetic association and loss-of-function experiments
limitations
Indexed abstract leaves individual construct details unresolved; no tissue-specific quantitative claim is made here.
nutrient_topic
Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
organism
Human genetic data and experimental cells
plain_language
A second research group supported the same transport step.
primary_references
[choline-p38977856] Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import. (2024). https://pubmed.ncbi.nlm.nih.gov/38977856/ DOI: 10.1038/s41588-024-01827-2
tissue_or_cell_type
Plasma choline and mitochondrial import
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 555–566
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Independent gene–metabolite mapping and mitochondrial experiments · source_derived_draft · unverified_draft
### choline-slc25a48-independent An independent GeneMAP study found that SLC25A48 loss strongly impaired mitochondrial choline import. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: A second research group supported the same transport step. organism: Human genetic data and experimental cells tissue_or_cell_type: Plasma choline and mitochondrial import experimental_model: Independent gene–metabolite mapping and mitochondrial experiments limitations: Indexed abstract leaves individual construct details unresolved; no tissue-specific quantitative claim is made here. exposure: SLC25A48 genetic association and loss-of-function experiments evidence_span: {"source_cache": "artifacts/choline-research/38977856.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "80a5e7038c33442cc887901558cb662b39fe4c54e3821f860c12a388c8a44c92", "start_char": 0, "end_char": 1169, "text_sha256": "80a5e7038c33442cc887901558cb662b39fe4c54e3821f860c12a388c8a44c92"} [choline-p38977856] Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import. (2024). https://pubmed.ncbi.nlm.nih.gov/38977856/ DOI: 10.1038/s41588-024-01827-2
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Human mitochondrial choline carrier SLC25A48