Component
Human mitochondrial glutamate carrier 2 / SLC25A18
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Reconstituted human glutamate carrier 2 also supported glutamate/proton-coupled transport, with kinetic and expression differences from carrier 1.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Recombinant human SLC25A18 compared with SLC25A22 in vesicle transport assays.
- limitations
- The proposed allocation to basal versus high-demand metabolism was an interpretation, not a universal tissue ranking.
- nutrient_topic
- L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Glutamate
- plain_language
- A related carrier is a separate node with its own properties.
- primary_references
- Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11897791/ · DOI 10.1074/jbc.M201572200
- transport_effect
- depends The record names the proton coupling and not which way glutamate crossed the membrane.
- transport_pool
- the mitochondrial matrix The record names the proton coupling and not which way glutamate crossed the membrane.
L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19) · lines 90–96
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Recombinant human SLC25A18 compared with SLC25A22 in vesicle transport assays. · source_derived_draft · unverified_draft
## glutamate-mitochondrial-gc2 A related carrier is a separate node with its own properties. Reconstituted human glutamate carrier 2 also supported glutamate/proton-coupled transport, with kinetic and expression differences from carrier 1. Model: Recombinant human SLC25A18 compared with SLC25A22 in vesicle transport assays. Limitations: The proposed allocation to basal versus high-demand metabolism was an interpretation, not a universal tissue ranking. Evidence access: Primary abstract Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11897791/ · DOI 10.1074/jbc.M201572200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.