Component

Human solute carrier SLC22A15

Context-specific entity; species, compartment and exposure are stated on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Human SLC22A15 expression enabled uptake of carnitine in HEK293 substrate assays.

    Human solute carrier SLC22A15 → L-Carnitine source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Metabolomic screening and uptake assays in transfected human cells.
    limitations
    Higher Km for ergothioneine, carnitine and carnosine than their established carriers; substrate sharing does not prove competition at dietary exposures.
    nutrient_topic
    Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
    plain_language
    An additional carrier connects carnitine to the transport network.
    primary_references
    Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33124720/ · DOI 10.1096/fj.202001497R
    transport_effect
    raises Expression enabled uptake in HEK293 substrate assays.
    transport_pool
    the expressing cell Expression enabled uptake in HEK293 substrate assays.

    Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 64–70

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Metabolomic screening and uptake assays in transfected human cells. · source_derived_draft · unverified_draft

    ## ergothioneine-slc22a15-carnitine An additional carrier connects carnitine to the transport network. Human SLC22A15 expression enabled uptake of carnitine in HEK293 substrate assays. Model: Metabolomic screening and uptake assays in transfected human cells. Limitations: Higher Km for ergothioneine, carnitine and carnosine than their established carriers; substrate sharing does not prove competition at dietary exposures. Evidence access: Primary abstract Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33124720/ · DOI 10.1096/fj.202001497R
    Complete structured claim and evidence

  2. Human SLC22A15 expression enabled uptake of carnosine in HEK293 substrate assays.

    Human solute carrier SLC22A15 → L-Carnosine / beta-alanyl-L-histidine source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Metabolomic screening and uptake assays in transfected human cells.
    limitations
    Higher Km for ergothioneine, carnitine and carnosine than their established carriers; substrate sharing does not prove competition at dietary exposures.
    nutrient_topic
    Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
    plain_language
    An additional carrier connects carnosine to the transport network.
    primary_references
    Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33124720/ · DOI 10.1096/fj.202001497R
    transport_effect
    raises Expression enabled uptake in HEK293 substrate assays.
    transport_pool
    the expressing cell Expression enabled uptake in HEK293 substrate assays.

    Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 56–62

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Metabolomic screening and uptake assays in transfected human cells. · source_derived_draft · unverified_draft

    ## ergothioneine-slc22a15-carnosine An additional carrier connects carnosine to the transport network. Human SLC22A15 expression enabled uptake of carnosine in HEK293 substrate assays. Model: Metabolomic screening and uptake assays in transfected human cells. Limitations: Higher Km for ergothioneine, carnitine and carnosine than their established carriers; substrate sharing does not prove competition at dietary exposures. Evidence access: Primary abstract Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33124720/ · DOI 10.1096/fj.202001497R
    Complete structured claim and evidence

  3. Human SLC22A15 expression enabled uptake of ergothioneine in HEK293 substrate assays.

    Human solute carrier SLC22A15 → L-Ergothioneine source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Metabolomic screening and uptake assays in transfected human cells.
    limitations
    Higher Km for ergothioneine, carnitine and carnosine than their established carriers; substrate sharing does not prove competition at dietary exposures.
    nutrient_topic
    Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
    plain_language
    An additional carrier connects ergothioneine to the transport network.
    primary_references
    Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33124720/ · DOI 10.1096/fj.202001497R
    transport_effect
    raises Expression enabled uptake in HEK293 substrate assays.
    transport_pool
    the expressing cell Expression enabled uptake in HEK293 substrate assays.

    Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 48–54

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Metabolomic screening and uptake assays in transfected human cells. · source_derived_draft · unverified_draft

    ## ergothioneine-slc22a15-ergo An additional carrier connects ergothioneine to the transport network. Human SLC22A15 expression enabled uptake of ergothioneine in HEK293 substrate assays. Model: Metabolomic screening and uptake assays in transfected human cells. Limitations: Higher Km for ergothioneine, carnitine and carnosine than their established carriers; substrate sharing does not prove competition at dietary exposures. Evidence access: Primary abstract Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33124720/ · DOI 10.1096/fj.202001497R
    Complete structured claim and evidence

  4. Human SLC22A15 expression enabled uptake of thiamine in HEK293 substrate assays.

    Human solute carrier SLC22A15 → Thiamine (vitamin B1) source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Metabolomic screening and uptake assays in transfected human cells.
    limitations
    Higher Km for ergothioneine, carnitine and carnosine than their established carriers; substrate sharing does not prove competition at dietary exposures.
    nutrient_topic
    Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
    plain_language
    An additional carrier connects thiamine to the transport network.
    primary_references
    Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33124720/ · DOI 10.1096/fj.202001497R
    transport_effect
    raises Expression enabled uptake in HEK293 substrate assays.
    transport_pool
    the expressing cell Expression enabled uptake in HEK293 substrate assays.

    Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 72–78

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Metabolomic screening and uptake assays in transfected human cells. · source_derived_draft · unverified_draft

    ## ergothioneine-slc22a15-thiamine An additional carrier connects thiamine to the transport network. Human SLC22A15 expression enabled uptake of thiamine in HEK293 substrate assays. Model: Metabolomic screening and uptake assays in transfected human cells. Limitations: Higher Km for ergothioneine, carnitine and carnosine than their established carriers; substrate sharing does not prove competition at dietary exposures. Evidence access: Primary abstract Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33124720/ · DOI 10.1096/fj.202001497R
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards