Component
SLC19A3 RNA abundance
Transcript measurement; not a direct measurement of transporter protein or vitamin flux.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After 28 days of experimental biotin depletion, leukocyte SLC19A3 RNA was 33% of baseline in seven adults.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- Human biotin availability was associated with SLC19A3 expression; functional B1 deficiency was not established.
- depleted-nutrient
- Biotin · Biotin
- evidence-scope
- Blood leukocytes
- evidence_locator
- Abstract
- evidence_spans
- [{"source_document": "artifacts/thiamine_transport_sources/vlasova-2005-biotin-slc19a3-source-record.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 1488}]
- experimental_model
- Seven evaluable adults before and after 28 days of an egg-white biotin-depleting diet.
- limitations
- No transporter protein, thiamine uptake or CNS endpoint measured.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Homo sapiens
- plain_language
- Low biotin changed expression of a B1-transporter gene.
- primary_references
- [vlasova-2005-biotin-slc19a3] Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood (2005). https://pubmed.ncbi.nlm.nih.gov/15623830/ DOI: 10.1093/jn/135.1.42
- tissue_or_cell_type
- Blood leukocytes
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 309–323
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Seven evaluable adults before and after 28 days of an egg-white biotin-depleting diet. · source_derived_draft · unverified_draft
### b1-biotin-depletion-slc19a3-rna After 28 days of experimental biotin depletion, leukocyte SLC19A3 RNA was 33% of baseline in seven adults. Condition category: nutrient_deficiency nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Low biotin changed expression of a B1-transporter gene. organism: Homo sapiens tissue_or_cell_type: Blood leukocytes experimental_model: Seven evaluable adults before and after 28 days of an egg-white biotin-depleting diet. limitations: No transporter protein, thiamine uptake or CNS endpoint measured. cross_nutrient: Human biotin availability was associated with SLC19A3 expression; functional B1 deficiency was not established. evidence_spans: [{"source_document": "artifacts/thiamine_transport_sources/vlasova-2005-biotin-slc19a3-source-record.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 1488}] evidence_locator: Abstract depleted-nutrient: Biotin evidence-scope: Blood leukocytes [vlasova-2005-biotin-slc19a3] Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood (2005). https://pubmed.ncbi.nlm.nih.gov/15623830/ DOI: 10.1093/jn/135.1.42
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.