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topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Low biotin changed expression of a B1-transporter gene.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[vlasova-2005-biotin-slc19a3] Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood (2005). https://pubmed.ncbi.nlm.nih.gov/15623830/ DOI: 10.1093/jn/135.1.42","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood leukocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"9ce3b8d9-8391-534a-ac03-6694f5d1c192","evidence_kind":"source_excerpt","locator":"Lines 309-323","start_line":309,"end_line":323,"excerpt":"### b1-biotin-depletion-slc19a3-rna\nAfter 28 days of experimental biotin depletion, leukocyte SLC19A3 RNA was 33% of baseline in seven adults.\nCondition category: nutrient_deficiency\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Low biotin changed expression of a B1-transporter gene.\norganism: Homo sapiens\ntissue_or_cell_type: Blood leukocytes\nexperimental_model: Seven evaluable adults before and after 28 days of an egg-white biotin-depleting diet.\nlimitations: No transporter protein, thiamine uptake or CNS endpoint measured.\ncross_nutrient: Human biotin availability was associated with SLC19A3 expression; functional B1 deficiency was not established.\nevidence_spans: [{\"source_document\": \"artifacts/thiamine_transport_sources/vlasova-2005-biotin-slc19a3-source-record.json\", \"source_field\": \"resultList.result[0].abstractText\", \"start_char\": 0, \"end_char\": 1488}]\nevidence_locator: Abstract\ndepleted-nutrient: Biotin\nevidence-scope: Blood leukocytes\n[vlasova-2005-biotin-slc19a3] Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood (2005). https://pubmed.ncbi.nlm.nih.gov/15623830/ DOI: 10.1093/jn/135.1.42","model_system":"Seven evaluable adults before and after 28 days of an egg-white biotin-depleting diet.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [vlasova-2005-biotin-slc19a3] Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood (2005). https://pubmed.ncbi.nlm.nih.gov/15623830/ DOI: 10.1093/jn/135.1.42","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}