Component
Human vesicular polyamine transporter / SLC18B1
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Purified human SLC18B1 transported spermidine into proteoliposomes by proton exchange.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Reconstituted purified human transporter.
- limitations
- Not a measurement of brain exposure after an oral supplement.
- nutrient_topic
- Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Spermidine
- plain_language
- Vesicles use a proton gradient to store polyamines.
- primary_references
- Identification of a mammalian vesicular polyamine transporter. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25355561/ · DOI 10.1038/srep06836
- transport_effect
- raises Recorded as transport of spermidine into proteoliposomes by proton exchange.
- transport_pool
- the secretory-vesicle lumen Recorded as transport of spermidine into proteoliposomes by proton exchange.
Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19) · lines 142–148
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Reconstituted purified human transporter. · source_derived_draft · unverified_draft
## spermidine-vesicle-transport Vesicles use a proton gradient to store polyamines. Purified human SLC18B1 transported spermidine into proteoliposomes by proton exchange. Model: Reconstituted purified human transporter. Limitations: Not a measurement of brain exposure after an oral supplement. Evidence access: Primary full text Identification of a mammalian vesicular polyamine transporter. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25355561/ · DOI 10.1038/srep06836
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.