Component
Skeletal muscle excitability
Skeletal muscle excitability; interpretation depends on linked experimental context.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
At 2 mM bath K, R528H muscle paradoxically depolarized and lost force while wild-type fibers hyperpolarized.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- A calcium-channel genetic defect changes potassium sensitivity of sodium-dependent muscle excitability.
- experimental_model
- 4.75 to 2 mM K challenge; mouse muscle recordings.
- limitations
- Sex/genotype influenced susceptibility; no general dietary-paralysis claim.
- nutrient_topic
- Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
- organism
- Mouse
- plain_language
- The same low-potassium exposure acted differently with inherited channel impairment.
- primary_references
- [wu-2012-hypopp] A calcium channel mutant mouse model of hypokalemic periodic paralysis (2012). https://pmc.ncbi.nlm.nih.gov/articles/PMC3533564/ DOI: 10.1172/JCI66091
- tissue_or_cell_type
- Skeletal muscle
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 762–772
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 4.75 to 2 mM K challenge; mouse muscle recordings. · source_derived_draft · unverified_draft
### k-hypopp-low-k-depolarization At 2 mM bath K, R528H muscle paradoxically depolarized and lost force while wild-type fibers hyperpolarized. Condition category: machinery_impairment nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same low-potassium exposure acted differently with inherited channel impairment. organism: Mouse tissue_or_cell_type: Skeletal muscle experimental_model: 4.75 to 2 mM K challenge; mouse muscle recordings. limitations: Sex/genotype influenced susceptibility; no general dietary-paralysis claim. cross_nutrient: A calcium-channel genetic defect changes potassium sensitivity of sodium-dependent muscle excitability. [wu-2012-hypopp] A calcium channel mutant mouse model of hypokalemic periodic paralysis (2012). https://pmc.ncbi.nlm.nih.gov/articles/PMC3533564/ DOI: 10.1172/JCI66091
Complete structured claim and evidenceInsulin stimulation of active Na-K transport restored M-wave area and force in the reduced-gradient soleus preparation.
Experimental context and source evidence
- cross_nutrient
- Hormonal stimulation coordinates sodium extrusion and potassium entry.
- experimental_model
- Rat soleus in 85 mM Na/9 mM K.
- limitations
- Ex vivo rescue is not a clinical intervention recommendation.
- nutrient_topic
- Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
- organism
- Rat
- plain_language
- Stimulating the shared sodium-potassium pump improved muscle responses.
- primary_references
- [overgaard-1999-muscle] Relations between excitability and contractility in rat soleus muscle: role of the Na+-K+ pump and Na+/K+ gradients (1999). https://pubmed.ncbi.nlm.nih.gov/10373703/ DOI: 10.1111/j.1469-7793.1999.0215r.x
- tissue_or_cell_type
- Soleus muscle
Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 727–737
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat soleus in 85 mM Na/9 mM K. · source_derived_draft · unverified_draft
### k-insulin-muscle-pump-rescue Insulin stimulation of active Na-K transport restored M-wave area and force in the reduced-gradient soleus preparation. Condition category: normal nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Stimulating the shared sodium-potassium pump improved muscle responses. organism: Rat tissue_or_cell_type: Soleus muscle experimental_model: Rat soleus in 85 mM Na/9 mM K. limitations: Ex vivo rescue is not a clinical intervention recommendation. cross_nutrient: Hormonal stimulation coordinates sodium extrusion and potassium entry. [overgaard-1999-muscle] Relations between excitability and contractility in rat soleus muscle: role of the Na+-K+ pump and Na+/K+ gradients (1999). https://pubmed.ncbi.nlm.nih.gov/10373703/ DOI: 10.1111/j.1469-7793.1999.0215r.x
Complete structured claim and evidenceThe combined 85 mM Na/9 mM K bath reduced M-wave area and tetanic force versus 147 mM Na/4 mM K.
Experimental context and source evidence
- cross_nutrient
- Reduced sodium and elevated potassium jointly impair excitability.
- experimental_model
- Isolated rat soleus, combined bath-ion perturbation.
- limitations
- Combined perturbation cannot be attributed to potassium alone; not dietary excess.
- nutrient_topic
- Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
- organism
- Rat
- plain_language
- Both sodium and potassium gradients matter for muscle activation.
- primary_references
- [overgaard-1999-muscle] Relations between excitability and contractility in rat soleus muscle: role of the Na+-K+ pump and Na+/K+ gradients (1999). https://pubmed.ncbi.nlm.nih.gov/10373703/ DOI: 10.1111/j.1469-7793.1999.0215r.x
- tissue_or_cell_type
- Soleus muscle
Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 715–725
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Isolated rat soleus, combined bath-ion perturbation. · source_derived_draft · unverified_draft
### k-na-gradients-muscle-excitability The combined 85 mM Na/9 mM K bath reduced M-wave area and tetanic force versus 147 mM Na/4 mM K. Condition category: normal nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Both sodium and potassium gradients matter for muscle activation. organism: Rat tissue_or_cell_type: Soleus muscle experimental_model: Isolated rat soleus, combined bath-ion perturbation. limitations: Combined perturbation cannot be attributed to potassium alone; not dietary excess. cross_nutrient: Reduced sodium and elevated potassium jointly impair excitability. [overgaard-1999-muscle] Relations between excitability and contractility in rat soleus muscle: role of the Na+-K+ pump and Na+/K+ gradients (1999). https://pubmed.ncbi.nlm.nih.gov/10373703/ DOI: 10.1111/j.1469-7793.1999.0215r.x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.