{"id":"4ca87f69-2d7e-5098-a120-12124cf69b1d","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-insulin-muscle-pump-rescue","predicate":"restores-excitability-under-reduced-gradients","statement":"Insulin stimulation of active Na-K transport restored M-wave area and force in the reduced-gradient soleus preparation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"569ec95c-5c10-50d1-b132-23dd76ad56dc","mechanism_event_label":"Stimulating the shared sodium-potassium pump improved muscle responses.","subject":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"object":{"id":"6dc31e65-7861-50e5-8b55-5890f612ae28","slug":"skeletal-muscle-excitability","display_name":"Skeletal muscle excitability","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"569ec95c-5c10-50d1-b132-23dd76ad56dc","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-insulin-muscle-pump-rescue-event","event_type":"biochemical_relationship","label":"Stimulating the shared sodium-potassium pump improved muscle responses.","description":"Insulin stimulation of active Na-K transport restored M-wave area and force in the reduced-gradient soleus preparation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"27c3e7bd-c6e1-5344-8130-b231a9da2cfb","slug":"sodium-potassium-atpase","display_name":"Sodium-potassium ATPase complexes","entity_type_key":"protein_family"},"role":"transport mediator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"gradient participant","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"gradient participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"6dc31e65-7861-50e5-8b55-5890f612ae28","slug":"skeletal-muscle-excitability","display_name":"Skeletal muscle excitability","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Hormonal stimulation coordinates sodium extrusion and potassium entry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat soleus in 85 mM Na/9 mM K.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ex vivo rescue is not a clinical intervention recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Stimulating the shared sodium-potassium pump improved muscle responses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[overgaard-1999-muscle] Relations between excitability and contractility in rat soleus muscle: role of the Na+-K+ pump and Na+/K+ gradients (1999). https://pubmed.ncbi.nlm.nih.gov/10373703/ DOI: 10.1111/j.1469-7793.1999.0215r.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Soleus muscle","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"309883c1-c861-5683-ac3d-f5ee47d78bd4","evidence_kind":"source_excerpt","locator":"Lines 727-737","start_line":727,"end_line":737,"excerpt":"### k-insulin-muscle-pump-rescue\nInsulin stimulation of active Na-K transport restored M-wave area and force in the reduced-gradient soleus preparation.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Stimulating the shared sodium-potassium pump improved muscle responses.\norganism: Rat\ntissue_or_cell_type: Soleus muscle\nexperimental_model: Rat soleus in 85 mM Na/9 mM K.\nlimitations: Ex vivo rescue is not a clinical intervention recommendation.\ncross_nutrient: Hormonal stimulation coordinates sodium extrusion and potassium entry.\n[overgaard-1999-muscle] Relations between excitability and contractility in rat soleus muscle: role of the Na+-K+ pump and Na+/K+ gradients (1999). https://pubmed.ncbi.nlm.nih.gov/10373703/ DOI: 10.1111/j.1469-7793.1999.0215r.x","model_system":"Rat soleus in 85 mM Na/9 mM K.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [overgaard-1999-muscle] Relations between excitability and contractility in rat soleus muscle: role of the Na+-K+ pump and Na+/K+ gradients (1999). https://pubmed.ncbi.nlm.nih.gov/10373703/ DOI: 10.1111/j.1469-7793.1999.0215r.x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}