Component
Viability of SkBr3, HEK-293 and fibroblast cells
Viability measured across cancer and non-cancer lines in one experiment.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Lariciresinol was tested for cellular toxicity and apoptosis induction in fibroblasts, HEK-293 cells and SkBr3 breast cancer cells, alongside podophyllotoxin and pinoresinol.
Experimental context and source evidence
- duration
- 24 and 48 hours
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- Human fibroblasts, HEK-293 and SkBr3 breast cancer cells
- exposure
- Lariciresinol at a range of concentrations for 24 and 48 hours
- limitations
- The abstract does not give the inhibitory concentrations for each line, so no selectivity between normal and cancer cells can be read from it here. SkBr3 is oestrogen receptor negative, so any activity in this line is independent of that receptor.
- organism
- Human fibroblasts, HEK-293 and SkBr3 breast cancer cells
- plain_language
- Lariciresinol was tested for cellular toxicity and apoptosis induction in fibroblasts, HEK-293 cells and SkBr3 breast cancer cells, alongside podophyllotoxin and pinoresinol.
- primary_references
- The Effect of Podophyllotoxin, Pinoresinol, and Lariciresinol on Cellular Toxicity and Apoptosis Induction in Fibroblast, HEK-293, and SkBr3 Cell Lines. (2024). https://pubmed.ncbi.nlm.nih.gov/38322161/ DOI: 10.30476/IJMS.2023.97113.2939
- route
- In vitro
- tissue
- Cell viability by MTT, apoptosis by flow cytometry, cell cycle and apoptosis regulator gene expression by quantitative PCR
Lariciresinol: five molecules under one name, and the mechanisms each one carries (2026-09-22) · lines 253–262
Original AI-assisted curation of twelve primary studies, every abstract read and all DOIs cross-checked against live PubMed metadata. Mechanism edges only, with no conclusion or claim of benefit recorded. Three author clusters account for eight of the twelve and carry shared laboratory keys. Study-specific concentrations, negative findings and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft
## lariciresinol-cytotoxicity-is-not-selective-for-cancer-cells Lariciresinol was tested for cellular toxicity and apoptosis induction in fibroblasts, HEK-293 cells and SkBr3 breast cancer cells, alongside podophyllotoxin and pinoresinol. Model/species: Human fibroblasts, HEK-293 and SkBr3 breast cancer cells Tissue/system: Cell viability by MTT, apoptosis by flow cytometry, cell cycle and apoptosis regulator gene expression by quantitative PCR Exposure: Lariciresinol at a range of concentrations for 24 and 48 hours Route: In vitro Duration: 24 and 48 hours Limits: The abstract does not give the inhibitory concentrations for each line, so no selectivity between normal and cancer cells can be read from it here. SkBr3 is oestrogen receptor negative, so any activity in this line is independent of that receptor. Primary reference: The Effect of Podophyllotoxin, Pinoresinol, and Lariciresinol on Cellular Toxicity and Apoptosis Induction in Fibroblast, HEK-293, and SkBr3 Cell Lines. (2024). https://pubmed.ncbi.nlm.nih.gov/38322161/ DOI: 10.30476/IJMS.2023.97113.2939 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.