Component
Sheep VPS35 protein
Ovis aries VPS35 retromer component; association evidence does not define complex stoichiometry.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Co-immunoprecipitation/Western blot experiments identified an association of sheep alpha-TTP with Vps35 in a liver/primary-hepatocyte study.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Co-IP/Western blot validation in sheep liver/hepatocyte study
- exposure
- Endogenous interaction profiling and validation; exact pull-down exposures not assigned from accessible sections.
- limitations
- Association is not proof of direct binary binding or a defined stable complex; no human nutritional outcome is inferred.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Ovis aries
- plain_language
- The sheep study linked this trafficking protein with alpha-TTP.
- primary_references
- [jian2025] Rab8a and Vps35 influence intracellular transport of vitamin E via α-Tocopherol transport protein in hepatocytes. (2025). https://pubmed.ncbi.nlm.nih.gov/40258550/ DOI: 10.1016/j.ijbiomac.2025.143021
- tissue_or_cell_type
- Liver and newborn male Australian White sheep primary hepatocytes
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 389–400
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Co-IP/Western blot validation in sheep liver/hepatocyte study · source_derived_draft · unverified_draft
### ve-transport-sheep-ttp-vps35 Co-immunoprecipitation/Western blot experiments identified an association of sheep alpha-TTP with Vps35 in a liver/primary-hepatocyte study. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: The sheep study linked this trafficking protein with alpha-TTP. organism: Ovis aries tissue_or_cell_type: Liver and newborn male Australian White sheep primary hepatocytes experimental_model: Co-IP/Western blot validation in sheep liver/hepatocyte study limitations: Association is not proof of direct binary binding or a defined stable complex; no human nutritional outcome is inferred. exposure: Endogenous interaction profiling and validation; exact pull-down exposures not assigned from accessible sections. cross_nutrient: false [jian2025] Rab8a and Vps35 influence intracellular transport of vitamin E via α-Tocopherol transport protein in hepatocytes. (2025). https://pubmed.ncbi.nlm.nih.gov/40258550/ DOI: 10.1016/j.ijbiomac.2025.143021
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.