Component
Severe prenatal iodine-deficiency neurological syndrome
Historical clinical outcome, defined by neurological and hearing/speech abnormalities in the trial; terminology and diagnostic criteria are retained in evidence, not applied as an individual diagnosis.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Among children conceived after maternal trial entry, the follow-up classified 0 of 237 in the iodinated-oil group and 14 of 215 in the saline group as definite cases of the historical neurological iodine-deficiency syndrome.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Primary PDF Methods p.69, Results and Fig2 pp.70–71; relevant pages visually inspected because OCR is imperfect.
- experimental_model
- Historical double-blind controlled maternal iodinated-oil trial begun 1966, with children born 1966–1972 followed through 1982 in five selected Papua New Guinea villages
- exposure
- Intramuscular iodinated oil versus saline; comparison by conception before/after maternal trial entry. The follow-up paper does not verify the injection dose in the inspected methods.
- limitations
- Long-term follow-up was restricted for logistical reasons to five of 13 original villages with high disease prevalence. Historical syndrome criteria and selection differ from modern mild-deficiency trials. Do not assume all developmental disorders were prevented or that established deficits were reversed. Two possible cases remained among the 237 treated-group children. Three definite treated-group cases in the overall 274 children had maternal treatment only at 30, 32 or 34 weeks gestation; this does not establish an exact universal gestational cutoff.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Homo sapiens
- plain_language
- In severe deficiency, supplying iodine before conception prevented the study-defined definite neurological syndrome in this follow-up.
- primary_references
- [iod-clin-pharoah1987] A controlled trial of iodinated oil for the prevention of endemic cretinism: a long-term follow-up. (1987). https://pubmed.ncbi.nlm.nih.gov/3032814/ DOI: 10.1093/ije/16.1.68
- tissue_or_cell_type
- Child neurological, hearing/speech and motor outcomes
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 1412–1424
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Historical double-blind controlled maternal iodinated-oil trial begun 1966, with children born 1966–1972 followed through 1982 in five selected Papua New Guinea villages · source_derived_draft · unverified_draft
### iod-clin-preconception-neurology Among children conceived after maternal trial entry, the follow-up classified 0 of 237 in the iodinated-oil group and 14 of 215 in the saline group as definite cases of the historical neurological iodine-deficiency syndrome. Condition category: nutrient_deficiency nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: In severe deficiency, supplying iodine before conception prevented the study-defined definite neurological syndrome in this follow-up. organism: Homo sapiens tissue_or_cell_type: Child neurological, hearing/speech and motor outcomes experimental_model: Historical double-blind controlled maternal iodinated-oil trial begun 1966, with children born 1966–1972 followed through 1982 in five selected Papua New Guinea villages limitations: Long-term follow-up was restricted for logistical reasons to five of 13 original villages with high disease prevalence. Historical syndrome criteria and selection differ from modern mild-deficiency trials. Do not assume all developmental disorders were prevented or that established deficits were reversed. Two possible cases remained among the 237 treated-group children. Three definite treated-group cases in the overall 274 children had maternal treatment only at 30, 32 or 34 weeks gestation; this does not establish an exact universal gestational cutoff. exposure: Intramuscular iodinated oil versus saline; comparison by conception before/after maternal trial entry. The follow-up paper does not verify the injection dose in the inspected methods. cross_nutrient: false evidence_location: Primary PDF Methods p.69, Results and Fig2 pp.70–71; relevant pages visually inspected because OCR is imperfect. [iod-clin-pharoah1987] A controlled trial of iodinated oil for the prevention of endemic cretinism: a long-term follow-up. (1987). https://pubmed.ncbi.nlm.nih.gov/3032814/ DOI: 10.1093/ije/16.1.68
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.