Component
Serum insulin-like growth factor I concentration
Serum insulin-like growth factor I concentration. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Serum IGF-I and IGF-binding protein 3 did not meaningfully differ between groups.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/26422197.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1327af281ec573be44c88b10fc7973e82e4963aab7bef3f7d14122e6c2a3dbea", "start_char": 0, "end_char": 1542, "text_sha256": "1327af281ec573be44c88b10fc7973e82e4963aab7bef3f7d14122e6c2a3dbea"}
- experimental_model
- Randomized six-month repeat-biopsy trial
- exposure
- Tomato extract containing 30 mg/day lycopene versus placebo
- limitations
- Small surrogate-endpoint study; exploratory histological extent findings were not established cancer prevention.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Human, 58 completers with high-grade prostatic intraepithelial neoplasia
- plain_language
- Cell-culture IGF signaling findings did not translate into these blood measurements.
- primary_references
- [lycopene-p26422197] A Phase II Randomized Trial of Lycopene-Rich Tomato Extract Among Men with High-Grade Prostatic Intraepithelial Neoplasia. (2015). https://pubmed.ncbi.nlm.nih.gov/26422197/ DOI: 10.1080/01635581.2015.1075560
- tissue_or_cell_type
- Serum biomarkers and prostate biopsies
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 1144–1155
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized six-month repeat-biopsy trial · source_derived_draft · unverified_draft
### lycopene-hgp-igf-null Serum IGF-I and IGF-binding protein 3 did not meaningfully differ between groups. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Cell-culture IGF signaling findings did not translate into these blood measurements. organism: Human, 58 completers with high-grade prostatic intraepithelial neoplasia tissue_or_cell_type: Serum biomarkers and prostate biopsies experimental_model: Randomized six-month repeat-biopsy trial limitations: Small surrogate-endpoint study; exploratory histological extent findings were not established cancer prevention. exposure: Tomato extract containing 30 mg/day lycopene versus placebo evidence_span: {"source_cache": "artifacts/lycopene-research/26422197.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1327af281ec573be44c88b10fc7973e82e4963aab7bef3f7d14122e6c2a3dbea", "start_char": 0, "end_char": 1542, "text_sha256": "1327af281ec573be44c88b10fc7973e82e4963aab7bef3f7d14122e6c2a3dbea"} [lycopene-p26422197] A Phase II Randomized Trial of Lycopene-Rich Tomato Extract Among Men with High-Grade Prostatic Intraepithelial Neoplasia. (2015). https://pubmed.ncbi.nlm.nih.gov/26422197/ DOI: 10.1080/01635581.2015.1075560
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.