Component
Serum holotranscobalamin concentration
Serum holotranscobalamin concentration
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
In the comparative diabetes study, adding oral calcium after three months of metformin reversed the decline in serum holo-transcobalamin.
Experimental context and source evidence
- cross_nutrient
- true
- experimental_model
- 21 adults with type 2 diabetes; 14 switched to metformin, then received calcium
- exposure
- Oral calcium after three months of metformin; dose not specified in inspected abstract
- limitations
- Small sequential comparative intervention. Serum holo-TC is an indirect absorption readout and does not directly prove membrane calcium antagonism.
- nutrient_topic
- Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
- organism
- Homo sapiens
- plain_language
- Calcium increased the circulating B12-carrier marker after metformin.
- primary_references
- [bauman-2000-calcium] Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. (2000). https://pubmed.ncbi.nlm.nih.gov/10977010/ DOI: 10.2337/diacare.23.9.1227
- tissue_or_cell_type
- Circulating holo-transcobalamin
Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 439–450
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 21 adults with type 2 diabetes; 14 switched to metformin, then received calcium · source_derived_draft · unverified_draft
### b12-abs-bauman-calcium-holotc In the comparative diabetes study, adding oral calcium after three months of metformin reversed the decline in serum holo-transcobalamin. Condition category: normal nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Calcium increased the circulating B12-carrier marker after metformin. organism: Homo sapiens tissue_or_cell_type: Circulating holo-transcobalamin experimental_model: 21 adults with type 2 diabetes; 14 switched to metformin, then received calcium limitations: Small sequential comparative intervention. Serum holo-TC is an indirect absorption readout and does not directly prove membrane calcium antagonism. exposure: Oral calcium after three months of metformin; dose not specified in inspected abstract cross_nutrient: true [bauman-2000-calcium] Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. (2000). https://pubmed.ncbi.nlm.nih.gov/10977010/ DOI: 10.2337/diacare.23.9.1227
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.