Component
Sepsis death or persistent organ dysfunction at day 28
Independent measured endpoint or substance; model, assay and exposure are retained in each linked finding.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The primary composite occurred in 44.5% with IV C versus 38.5% with placebo (RR 1.21, 95% CI 1.04–1.40; P=0.01).
Experimental context and source evidence
- experimental_model
- LOVIT: multicenter placebo-controlled randomized ICU trial; 872 randomized, 863 in primary analysis, with sepsis and vasopressor use.
- exposure
- IV vitamin C 50 mg/kg every six hours for up to 96 hours versus matched placebo.
- limitations
- The trial did not identify the molecular cause; pharmacologic IV exposure cannot be generalized to food vitamin C or correction of scurvy.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Homo sapiens
- plain_language
- In this sepsis population, the tested infusion increased the combined risk of death or ongoing organ-support needs.
- primary_references
- [c-lamontagne2022] Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit (2022). https://pubmed.ncbi.nlm.nih.gov/35704292/ DOI: 10.1056/nejmoa2200644
- tissue_or_cell_type
- Human blood or whole-person endpoints
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1695–1705
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · LOVIT: multicenter placebo-controlled randomized ICU trial; 872 randomized, 863 in primary analysis, with sepsis and vasopressor use. · source_derived_draft · unverified_draft
### c-lovit-primary-composite The primary composite occurred in 44.5% with IV C versus 38.5% with placebo (RR 1.21, 95% CI 1.04–1.40; P=0.01). Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: In this sepsis population, the tested infusion increased the combined risk of death or ongoing organ-support needs. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: LOVIT: multicenter placebo-controlled randomized ICU trial; 872 randomized, 863 in primary analysis, with sepsis and vasopressor use. limitations: The trial did not identify the molecular cause; pharmacologic IV exposure cannot be generalized to food vitamin C or correction of scurvy. exposure: IV vitamin C 50 mg/kg every six hours for up to 96 hours versus matched placebo. [c-lamontagne2022] Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit (2022). https://pubmed.ncbi.nlm.nih.gov/35704292/ DOI: 10.1056/nejmoa2200644
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.