{"id":"33e7ba84-7e48-58db-968d-af80ed10fa33","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-lovit-primary-composite","predicate":"increased_sepsis_primary_composite_risk","statement":"The primary composite occurred in 44.5% with IV C versus 38.5% with placebo (RR 1.21, 95% CI 1.04–1.40; P=0.01).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"b3941c3a-50bf-5cdd-9b1e-3aeba71b9d77","mechanism_event_label":"In this sepsis population, the tested infusion increased the combined risk of death or ongoing organ-support needs.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"eeab54ff-d71d-53d0-a128-d8466a8acc27","slug":"sepsis-death-or-persistent-organ-dysfunction-day28","display_name":"Sepsis death or persistent organ dysfunction at day 28","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b3941c3a-50bf-5cdd-9b1e-3aeba71b9d77","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-lovit-primary-composite-event","event_type":"observed_intervention","label":"In this sepsis population, the tested infusion increased the combined risk of death or ongoing organ-support needs.","description":"The primary composite occurred in 44.5% with IV C versus 38.5% with placebo (RR 1.21, 95% CI 1.04–1.40; P=0.01).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"eeab54ff-d71d-53d0-a128-d8466a8acc27","slug":"sepsis-death-or-persistent-organ-dysfunction-day28","display_name":"Sepsis death or persistent organ dysfunction at day 28","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"LOVIT: multicenter placebo-controlled randomized ICU trial; 872 randomized, 863 in primary analysis, with sepsis and vasopressor use.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"IV vitamin C 50 mg/kg every six hours for up to 96 hours versus matched placebo.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The trial did not identify the molecular cause; pharmacologic IV exposure cannot be generalized to food vitamin C or correction of scurvy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In this sepsis population, the tested infusion increased the combined risk of death or ongoing organ-support needs.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[c-lamontagne2022] Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit (2022). https://pubmed.ncbi.nlm.nih.gov/35704292/ DOI: 10.1056/nejmoa2200644","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b0ffa31b-6cc1-5933-b3f3-4ec14e673605","evidence_kind":"source_excerpt","locator":"Lines 1695-1705","start_line":1695,"end_line":1705,"excerpt":"### c-lovit-primary-composite\nThe primary composite occurred in 44.5% with IV C versus 38.5% with placebo (RR 1.21, 95% CI 1.04–1.40; P=0.01).\nCondition category: normal\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: In this sepsis population, the tested infusion increased the combined risk of death or ongoing organ-support needs.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: LOVIT: multicenter placebo-controlled randomized ICU trial; 872 randomized, 863 in primary analysis, with sepsis and vasopressor use.\nlimitations: The trial did not identify the molecular cause; pharmacologic IV exposure cannot be generalized to food vitamin C or correction of scurvy.\nexposure: IV vitamin C 50 mg/kg every six hours for up to 96 hours versus matched placebo.\n[c-lamontagne2022] Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit (2022). https://pubmed.ncbi.nlm.nih.gov/35704292/ DOI: 10.1056/nejmoa2200644","model_system":"LOVIT: multicenter placebo-controlled randomized ICU trial; 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Study references: [c-lamontagne2022] Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit (2022). https://pubmed.ncbi.nlm.nih.gov/35704292/ DOI: 10.1056/nejmoa2200644","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b7fd83f956abb81855f2ea23199ba14e465cd91f4a2ac560277ec21ddafd7bfc","revision_id":"6cde9bbb-d712-5746-82a6-85b144253efa","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}