Component
Rodent fetal malformations during maternal biotin deprivation
Rodent fetal malformations during maternal biotin deprivation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Maternal biotin deprivation caused severe malformations in mice, no observed fetal malformations in rats, and high embryonic lethality in hamsters.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/biotin-research/2918398.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a278d26fdd2c475c22b9b7f8cdeb6e11720872342805cab9ee6886ede7380bc3", "start_char": 0, "end_char": 812, "text_sha256": "a278d26fdd2c475c22b9b7f8cdeb6e11720872342805cab9ee6886ede7380bc3"}
- experimental_model
- Maternal biotin-deprivation comparison across mice, rats and Syrian hamsters
- exposure
- Biotin deprivation during gestation
- limitations
- Strong species and strain differences; this does not prove biotin deficiency causes the same malformations in humans.
- nutrient_topic
- Biotin research collection; topical membership is not evidence of a direct dietary effect. · Biotin
- organism
- Mus musculus; Rattus norvegicus; Mesocricetus auratus
- plain_language
- Animal findings establish vulnerability while also showing why direct human extrapolation is unsafe.
- primary_references
- [b7-p2918398] Species and strain differences in teratogenic effects of biotin deficiency in rodents. (1989). https://pubmed.ncbi.nlm.nih.gov/2918398/ DOI: 10.1093/jn/119.2.255
- tissue_or_cell_type
- Maternal-fetal systems
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Biotin: carboxylases, recycling, deficiency and nutrient interactions (2026-09-17) · lines 1014–1025
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Maternal biotin-deprivation comparison across mice, rats and Syrian hamsters · source_derived_draft · unverified_draft
### b7-rodent-teratogenesis Maternal biotin deprivation caused severe malformations in mice, no observed fetal malformations in rats, and high embryonic lethality in hamsters. Condition category: nutrient_deficiency nutrient_topic: Biotin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Animal findings establish vulnerability while also showing why direct human extrapolation is unsafe. organism: Mus musculus; Rattus norvegicus; Mesocricetus auratus tissue_or_cell_type: Maternal-fetal systems experimental_model: Maternal biotin-deprivation comparison across mice, rats and Syrian hamsters limitations: Strong species and strain differences; this does not prove biotin deficiency causes the same malformations in humans. exposure: Biotin deprivation during gestation evidence_span: {"source_cache": "artifacts/biotin-research/2918398.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a278d26fdd2c475c22b9b7f8cdeb6e11720872342805cab9ee6886ede7380bc3", "start_char": 0, "end_char": 812, "text_sha256": "a278d26fdd2c475c22b9b7f8cdeb6e11720872342805cab9ee6886ede7380bc3"} [b7-p2918398] Species and strain differences in teratogenic effects of biotin deficiency in rodents. (1989). https://pubmed.ncbi.nlm.nih.gov/2918398/ DOI: 10.1093/jn/119.2.255
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.