{"id":"90e1614e-fd2d-51d3-9c00-4c37cc5472c3","stable_key":"08ce9896-9d1c-5bbf-b705-5bfe771091d5:b7-rodent-teratogenesis","predicate":"deprivation_has_species_specific_effects","statement":"Maternal biotin deprivation caused severe malformations in mice, no observed fetal malformations in rats, and high embryonic lethality in hamsters.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fceaa3cf-1232-5825-8b6d-bf0ee8365067","mechanism_event_label":"Animal findings establish vulnerability while also showing why direct human extrapolation is unsafe.","subject":{"id":"37a8e96b-f95b-5ba7-a0bc-8ed3cfaf5fd8","slug":"biotin","display_name":"Biotin","entity_type_key":"small_molecule"},"object":{"id":"4d35dddc-f5e8-54e9-92e0-8a274819388c","slug":"rodent-fetal-malformations","display_name":"Rodent fetal malformations during maternal biotin deprivation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fceaa3cf-1232-5825-8b6d-bf0ee8365067","stable_key":"08ce9896-9d1c-5bbf-b705-5bfe771091d5:b7-rodent-teratogenesis-event","event_type":"observed_intervention","label":"Animal findings establish vulnerability while also showing why direct human extrapolation is unsafe.","description":"Maternal biotin deprivation caused severe malformations in mice, no observed fetal malformations in rats, and high embryonic lethality in hamsters.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"37a8e96b-f95b-5ba7-a0bc-8ed3cfaf5fd8","slug":"biotin","display_name":"Biotin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4d35dddc-f5e8-54e9-92e0-8a274819388c","slug":"rodent-fetal-malformations","display_name":"Rodent fetal malformations during maternal biotin deprivation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/biotin-research/2918398.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a278d26fdd2c475c22b9b7f8cdeb6e11720872342805cab9ee6886ede7380bc3\", \"start_char\": 0, \"end_char\": 812, \"text_sha256\": \"a278d26fdd2c475c22b9b7f8cdeb6e11720872342805cab9ee6886ede7380bc3\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Maternal biotin-deprivation comparison across mice, rats and Syrian hamsters","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Biotin deprivation during gestation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Strong species and strain differences; this does not prove biotin deficiency causes the same malformations in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Biotin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"biotin","display_name":"Biotin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mus musculus; Rattus norvegicus; Mesocricetus auratus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Animal findings establish vulnerability while also showing why direct human extrapolation is unsafe.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b7-p2918398] Species and strain differences in teratogenic effects of biotin deficiency in rodents. (1989). https://pubmed.ncbi.nlm.nih.gov/2918398/ DOI: 10.1093/jn/119.2.255","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Maternal-fetal systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"a165ef38-7e96-56e0-a0c4-c4ffdeb1389a","evidence_kind":"source_excerpt","locator":"Lines 1014-1025","start_line":1014,"end_line":1025,"excerpt":"### b7-rodent-teratogenesis\nMaternal biotin deprivation caused severe malformations in mice, no observed fetal malformations in rats, and high embryonic lethality in hamsters.\nCondition category: nutrient_deficiency\nnutrient_topic: Biotin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Animal findings establish vulnerability while also showing why direct human extrapolation is unsafe.\norganism: Mus musculus; Rattus norvegicus; Mesocricetus auratus\ntissue_or_cell_type: Maternal-fetal systems\nexperimental_model: Maternal biotin-deprivation comparison across mice, rats and Syrian hamsters\nlimitations: Strong species and strain differences; this does not prove biotin deficiency causes the same malformations in humans.\nexposure: Biotin deprivation during gestation\nevidence_span: {\"source_cache\": \"artifacts/biotin-research/2918398.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a278d26fdd2c475c22b9b7f8cdeb6e11720872342805cab9ee6886ede7380bc3\", \"start_char\": 0, \"end_char\": 812, \"text_sha256\": \"a278d26fdd2c475c22b9b7f8cdeb6e11720872342805cab9ee6886ede7380bc3\"}\n[b7-p2918398] Species and strain differences in teratogenic effects of biotin deficiency in rodents. (1989). https://pubmed.ncbi.nlm.nih.gov/2918398/ DOI: 10.1093/jn/119.2.255","model_system":"Maternal biotin-deprivation comparison across mice, rats and Syrian hamsters","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b7-p2918398] Species and strain differences in teratogenic effects of biotin deficiency in rodents. (1989). https://pubmed.ncbi.nlm.nih.gov/2918398/ DOI: 10.1093/jn/119.2.255","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9608806b-adb6-5a35-b042-057147135642","stable_key":"import-08ce9896-9d1c-5bbf-b705-5bfe771091d5","title":"Biotin: carboxylases, recycling, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a05b23a45e0813ba2fcda0027e3f5d9d58b82858f8dd8598ffb7aca17e942a38","revision_id":"e0d0c2a2-e9e2-55dd-b467-41c22ba960d4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}