Component
Rodent tissue ferroportin protein abundance
Rodent tissue ferroportin protein abundance. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Dietary copper deficiency caused little ferroportin mRNA change; protein responses varied and did not account for the anemia across the rodent models.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/copper-research/22294464.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "008de3f1f584a29a0ce082e6423042ed21585064b2dc900802103fc00b3fee8e", "start_char": 0, "end_char": 1578, "text_sha256": "008de3f1f584a29a0ce082e6423042ed21585064b2dc900802103fc00b3fee8e"}
- experimental_model
- Dietary copper-deficient rat and mouse tissue comparisons
- exposure
- Dietary copper depletion
- limitations
- Tissue ferroportin responses were complex and did not explain copper-deficiency anemia. Do not generalize genetic GPI-ceruloplasmin absence into universal ferroportin destruction during nutritional copper deficiency.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Rat and mouse
- plain_language
- There is no single demonstrated switch that destroys every iron exporter when copper falls.
- primary_references
- [copper-p22294464] Copper deficiency has minimal impact on ferroportin expression or function. (2012). https://pubmed.ncbi.nlm.nih.gov/22294464/ DOI: 10.1007/s10534-012-9521-2
- tissue_or_cell_type
- Liver, spleen and intestinal iron-related tissues
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 884–895
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary copper-deficient rat and mouse tissue comparisons · source_derived_draft · unverified_draft
### copper-cud-ferroportin-boundary Dietary copper deficiency caused little ferroportin mRNA change; protein responses varied and did not account for the anemia across the rodent models. Condition category: nutrient_deficiency nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: There is no single demonstrated switch that destroys every iron exporter when copper falls. organism: Rat and mouse tissue_or_cell_type: Liver, spleen and intestinal iron-related tissues experimental_model: Dietary copper-deficient rat and mouse tissue comparisons limitations: Tissue ferroportin responses were complex and did not explain copper-deficiency anemia. Do not generalize genetic GPI-ceruloplasmin absence into universal ferroportin destruction during nutritional copper deficiency. exposure: Dietary copper depletion evidence_span: {"source_cache": "artifacts/copper-research/22294464.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "008de3f1f584a29a0ce082e6423042ed21585064b2dc900802103fc00b3fee8e", "start_char": 0, "end_char": 1578, "text_sha256": "008de3f1f584a29a0ce082e6423042ed21585064b2dc900802103fc00b3fee8e"} [copper-p22294464] Copper deficiency has minimal impact on ferroportin expression or function. (2012). https://pubmed.ncbi.nlm.nih.gov/22294464/ DOI: 10.1007/s10534-012-9521-2
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.